Issue 23, 2023

Recent advances in trifluoroethylation reaction

Abstract

Trifluoroethyl group serving as the bioisostere of ethyl or ethoxy group widely exists in the fields of pharmaceuticals and agrochemicals. Developing novel strategies for introducing trifluoroethyl group into various skeletons has become a hot topic in organic synthetic chemistry. In this review, the trifluoroethylation reactions on various compounds such as alkynes, alkenes, functionalized arenes, amines, and so on were summarized. This review is categorized into four parts based on the bond formation: C(sp)–CH2CF3, C(sp2)–CH2CF3, C(sp3)–CH2CF3, and X (X = N, O, S, and Se)–CH2CF3. Some representative examples along with reaction mechanisms were also discussed.

Graphical abstract: Recent advances in trifluoroethylation reaction

Article information

Article type
Review Article
Submitted
24 Aug 2023
Accepted
02 Okt 2023
First published
04 Okt 2023

Org. Chem. Front., 2023,10, 5986-6009

Recent advances in trifluoroethylation reaction

M. Zhou, S. Han, Y. Wang, W. Zhang, Z. Wang and Y. Zeng, Org. Chem. Front., 2023, 10, 5986 DOI: 10.1039/D3QO01366A

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