Issue 11, 2022

Impurity incorporation in solution crystallization: diagnosis, prevention, and control

Abstract

Despite their widespread use for purification, our current methods for the development of solution crystallization processes lack a sufficient understanding on how impurities incorporate in growing crystals. This is, in part, due to the large number of mechanisms often encountered for impurity incorporation, and due to limitations in our methods for diagnosis of those mechanisms. These limitations propagate into largely empirical process development strategies, which are still based on trial and error and centered on solvent selection. This manuscript highlights recent developments in the diagnosis, prevention, and control of impurity incorporation during batch and continuous crystallization. The goal is to provide process development scientists with an updated toolkit for understanding how specific impurities are retained in the solid product, and to review recent prevention and control strategies that may be used to improve crystal purity in industrial crystallization processes.

Graphical abstract: Impurity incorporation in solution crystallization: diagnosis, prevention, and control

Article information

Article type
Highlight
Submitted
28 Dez 2021
Accepted
04 Feb 2022
First published
07 Feb 2022
This article is Open Access
Creative Commons BY-NC license

CrystEngComm, 2022,24, 1989-2001

Impurity incorporation in solution crystallization: diagnosis, prevention, and control

G. Capellades, J. O. Bonsu and A. S. Myerson, CrystEngComm, 2022, 24, 1989 DOI: 10.1039/D1CE01721G

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