Issue 97, 2022

Prebiotic triose glycolysis promoted by co-catalytic proline and phosphate in neutral water

Abstract

Proline and phosphate promote a near-quantitative aldol reaction between glycolaldehyde phosphate and formaldehyde at neutral pH in water. Our results demonstrate the important role of general acid-base catalysis in water and underscore the essential role that amino acid catalysis may have played in early evolution of life's core metabolic pathways.

Graphical abstract: Prebiotic triose glycolysis promoted by co-catalytic proline and phosphate in neutral water

Supplementary files

Article information

Article type
Communication
Submitted
06 Okt 2022
Accepted
14 Nov 2022
First published
14 Nov 2022
This article is Open Access
Creative Commons BY license

Chem. Commun., 2022,58, 13519-13522

Prebiotic triose glycolysis promoted by co-catalytic proline and phosphate in neutral water

Á. F. Magalhães and M. W. Powner, Chem. Commun., 2022, 58, 13519 DOI: 10.1039/D2CC05466C

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