Issue 57, 2021

Conversion of N-acyl amidines to amidoximes: a convenient synthetic approach to molnupiravir (EIDD-2801) from ribose

Abstract

An efficient method is described for the preparation of molnupiravir (EIDD-2801) an antiviral agent via regioselective conversion of an N-acyl-nucleoside intermediate, generated through stereo and regioselective glycosylation of protected ribose and N4-acetyl cytosine, to an amidoxime. This method avoids use of expensive starting materials, enzymes, complex reagents, and cumbersome purification procedures.

Graphical abstract: Conversion of N-acyl amidines to amidoximes: a convenient synthetic approach to molnupiravir (EIDD-2801) from ribose

Associated articles

Supplementary files

Article information

Article type
Paper
Submitted
15 Sep 2021
Accepted
27 Okt 2021
First published
10 Nov 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 36143-36147

Conversion of N-acyl amidines to amidoximes: a convenient synthetic approach to molnupiravir (EIDD-2801) from ribose

A. Ahmed, Q. N. Ahmed and D. Mukherjee, RSC Adv., 2021, 11, 36143 DOI: 10.1039/D1RA06912H

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