Issue 23, 2021

Nickel-catalyzed electrochemical reductive relay cross-coupling of alkyl halides with alkyl carboxylic acids

Abstract

A highly regioselective Ni-catalyzed electrochemical (undivided cell) reductive relay cross-coupling between alkyl carboxylic acids and alkyl bromides has been developed. This strategy allows the direct acylation of benzylic C(sp3)–H bonds in good yields from commercially available alkyl carboxylic acids, thus providing an alternative strategy for the synthesis of dialkyl ketones. Various functional groups are tolerated under mild reaction conditions.

Graphical abstract: Nickel-catalyzed electrochemical reductive relay cross-coupling of alkyl halides with alkyl carboxylic acids

Supplementary files

Article information

Article type
Research Article
Submitted
16 Aug 2021
Accepted
07 Okt 2021
First published
07 Okt 2021

Org. Chem. Front., 2021,8, 6603-6608

Nickel-catalyzed electrochemical reductive relay cross-coupling of alkyl halides with alkyl carboxylic acids

K. Jiao, C. Ma, D. Liu, H. Qiu, B. Cheng and T. Mei, Org. Chem. Front., 2021, 8, 6603 DOI: 10.1039/D1QO01219C

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