Issue 44, 2020

Applications of decellularized materials in tissue engineering: advantages, drawbacks and current improvements, and future perspectives

Abstract

Decellularized materials (DMs) are attracting more and more attention because of their native structures, comparatively high bioactivity, low immunogenicity and good biodegradability, which are difficult to be imitated by synthetic materials. Recently, DMs have been demonstrated to possess great potential to overcome the disadvantages of autografts and have become a kind of promising material for tissue engineering. In this systematic review, we aimed to not only provide a quick access for understanding DMs, but also bring new ideas to utilize them more appropriately in tissue engineering. Firstly, the preparation of DMs was introduced. Then, the updated applications of DMs derived from different tissues and organs in tissue engineering were comprehensively summarized. In particular, their advantages, drawbacks and current improvements were emphasized. Moreover, we analyzed and proposed future perspectives.

Graphical abstract: Applications of decellularized materials in tissue engineering: advantages, drawbacks and current improvements, and future perspectives

Article information

Article type
Review Article
Submitted
19 Jun 2020
Accepted
02 Okt 2020
First published
03 Okt 2020

J. Mater. Chem. B, 2020,8, 10023-10049

Applications of decellularized materials in tissue engineering: advantages, drawbacks and current improvements, and future perspectives

J. Liao, B. Xu, R. Zhang, Y. Fan, H. Xie and X. Li, J. Mater. Chem. B, 2020, 8, 10023 DOI: 10.1039/D0TB01534B

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