Issue 2, 2017

Palladium-catalyzed asymmetric allylic amination: enantioselective synthesis of chiral α-methylene substituted β-aminophosphonates

Abstract

Spiroketal backbone based diphosphine ligands (SKP) were disclosed to be highly efficient and enantioselective (94 → 99% ee) in the palladium catalyzed asymmetric allylic amination of 2-diethylphosphonate-substituted allylic acetates, affording a series of chiral β-aminophosphonates bearing an α-methylene functionality in high yields with excellent regioselectivities.

Graphical abstract: Palladium-catalyzed asymmetric allylic amination: enantioselective synthesis of chiral α-methylene substituted β-aminophosphonates

Supplementary files

Article information

Article type
Research Article
Submitted
07 Okt 2016
Accepted
25 Nov 2016
First published
29 Nov 2016

Org. Chem. Front., 2017,4, 271-276

Palladium-catalyzed asymmetric allylic amination: enantioselective synthesis of chiral α-methylene substituted β-aminophosphonates

X. Wang, X. Wang, Z. Han, Z. Wang and K. Ding, Org. Chem. Front., 2017, 4, 271 DOI: 10.1039/C6QO00597G

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