Issue 24, 2023

A high performance AIE-active sonosensitizer for efficient sonodynamic tumor therapy

Abstract

Ultrasound-triggered sonodynamic therapy (SDT) presents growing promise in deep-seated or unresectable tumor inhibition because of the perfect tissue penetration ability. However, its therapeutic efficacy is always restricted by the limited reactive oxygen species (ROS) generation ability of sonosensitizers. In this work, based on molecular engineering, we have fabricated aggregation-induced emission (AIE)-active organic sonosensitizers bearing efficient ROS generation with US irradiation for tumor treatment. By enhancing the intramolecular charge transfer strength and intermolecular interaction, an organic sonosensitizer with reduced energy gap and AIE features was developed, presenting enhanced oxygen sensitization behavior to produce ROS upon an ultrasound trigger compared to Ce 6. Moreover, the excellent mitochondrial enrichment of the obtained sonosensitizer enables effective tumor cell eradication via apoptotic and ferroptosis pathways with ultrasound irradiation. The efficient in vivo tumor inhibition was also achieved based on the SDT approach. Therefore, this work provided a generalized and promising strategy for deep-seated or unresectable tumor treatment in the clinic.

Graphical abstract: A high performance AIE-active sonosensitizer for efficient sonodynamic tumor therapy

Supplementary files

Article information

Article type
Research Article
Submitted
09 Aug 2023
Accepted
10 Okt 2023
First published
13 Okt 2023

Mater. Chem. Front., 2023,7, 6229-6235

A high performance AIE-active sonosensitizer for efficient sonodynamic tumor therapy

W. Zhao, C. Fu, H. Gao, Y. Zhou, C. Yan, Y. Yin, R. Hu and B. Z. Tang, Mater. Chem. Front., 2023, 7, 6229 DOI: 10.1039/D3QM00842H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements