Issue 22, 2022

Formamidation of a wide range of substituted and functionalized amines with CO and a base

Abstract

Current methods for preparing formamides are limited by the narrow substrate scope and requirement for harsh reaction conditions. A base-mediated formamidation of amines with CO (<2 bar) under mild conditions was developed, which enabled the synthesis of a wide range of formamides in 61% to 98% yields under transition-metal-free conditions. This provides a useful strategy for generating gram amounts of various aromatic and aliphatic amides.

Graphical abstract: Formamidation of a wide range of substituted and functionalized amines with CO and a base

Supplementary files

Article information

Article type
Research Article
Submitted
16 Aug 2022
Accepted
03 Okt 2022
First published
05 Okt 2022

Org. Chem. Front., 2022,9, 6142-6148

Formamidation of a wide range of substituted and functionalized amines with CO and a base

C. Zhang, Y. Zhang, Q. Liang, G. Zhang, W. Yang, N. Li, G. Qin and G. Zhang, Org. Chem. Front., 2022, 9, 6142 DOI: 10.1039/D2QO01312F

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