Issue 46, 2021

In situ construction of a nano-structured akermanite coating for promoting bone formation and osseointegration of Ti–6Al–4V implants in a rabbit osteoporosis model

Abstract

With the aging population worldwide, osteoporosis, as an age-related bone metabolic disease, is becoming a hot issue in public health. However, it is still a great challenge to realize osteoporotic bone healing due to the alteration of the bone microenvironment in osteoporosis patients. In this study, a nano-structured akermanite (nAK) coating was in situ constructed on Ti–6Al–4V implants to improve osteoporotic bone repair. In vitro studies indicated that both the surface nano-topography and bioactive ions released from the nAK coatings promoted the proliferation, osteogenesis, angiogenesis and inhibited osteoclastogenesis of ovariectomy rabbit-derived bone marrow mesenchymal stem cells (OVX-rBMSCs). Furthermore, the nAK-coated Ti–6Al–4V implants improved new bone formation and osseointegration in an osteoporosis rabbit model in vivo. These results indicated that the AK coating with a nano-structured surface on the Ti–6Al–4V implant could synergistically promote bone formation and osseointegration for osteoporosis patients. This may be a promising strategy to improve the bone regeneration and osseointegration capability of orthopedic implants under osteoporosis conditions.

Graphical abstract: In situ construction of a nano-structured akermanite coating for promoting bone formation and osseointegration of Ti–6Al–4V implants in a rabbit osteoporosis model

Article information

Article type
Paper
Submitted
02 Sep 2021
Accepted
21 Okt 2021
First published
08 Nov 2021

J. Mater. Chem. B, 2021,9, 9505-9513

In situ construction of a nano-structured akermanite coating for promoting bone formation and osseointegration of Ti–6Al–4V implants in a rabbit osteoporosis model

J. Cui, L. Xia, K. Lin and X. Wang, J. Mater. Chem. B, 2021, 9, 9505 DOI: 10.1039/D1TB01917A

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