Triflic acid-mediated protocol for the synthesis of N-(pyrrolidine-3-ylidenemethyl)acetamide and its piperidine analogue in good yields with separable Z/E isomer has been demonstrated.
Dihydro[1,2,3]triazolo-pyrimidoisoindolones and dihydro[1,2,3]triazolo-diazepinoisoindolones can conveniently be synthesized from sodium azide and alkyne substituted amido alcohols in good yields using the Huisgen reaction.
An efficient synthesis of 4,4-dihalopiperidines from N-(3-halobut-3-en-1-yl)-4-methylbenzenesulfonamide has been unveiled. 4,4-Dihalopiperidines have been transformed in one step into piperidin-4-ones, pyridines and enol ethers in reasonable yields.
A highly sustainable, bench-stable, inexpensive, non-toxic and commercially available N-heterocyclic carbene based hydrogen borrowing organocatalyst for the direct N-alkylation of amines with alcohols is reported.
Novel dual acting benzofuran-based chromenochalcones were synthesized and assessed for in vitro and in vivo antihyperglycemic and antidyslipidemic activities.