The review highlights the use of Ugi multicomponent reactions and subsequent transformation strategies to create diverse indole frameworks in enantioselective and diastereoselective manner, underscoring their vital importance in medicinal chemistry.
This work utilises high-end molecular modelling techniques to analyse a drug target with known inhibitors and design molecules based on it, subsequently leading to the development of novel antitubercular agents.
A new series of 5-substituted-3-ethylindole-2-carboxamides 5a–k and 6a–c was designed and synthesised in an attempt to develop a dual targeted antiproliferative agent.
We described the application of C–H functionalization for constructing carbazole-based biaryls and their anticancer activities in cancer cell lines, e.g., HeLa, HCT116, MDA-MB-231 and MDA-MB-468 and the human embryonic kidney cell line HEK293T.
The hypolipidemic effect of furan carboxamide derivatives was investigated using the Triton WR-1339 rat model.