A series of highly potent and selective CYP1B1 inhibitors based on N-phenyl-[2,4′-bithiazol]-2′-amine were obtained and their structure–activity-relationships were analyzed.
Vanillin's biotransformation by CYP450 was studied, identifying aldehyde deformylation as energy-efficient pathway. Docking and MD simulations showed stable interactions with CYP2E1 and CYP1A2, suggesting potential food safety implications.
Stilbenes are polyphenolic secondary metabolites produced in a variety of plant species and show divers biological activities.
The electrochemistry of heme-containing enzymes (including cytochrome P450s and peroxidases) and their applications in electrosynthesis are reviewed.
Cytochrome P450 metabolism characteristics of [6]-gingerol, [8]-gingerol, and [10]-gingerol.