Nine undescribed carotane sesquiterpenes and rare rearranged guaiane sesquiterpenoids (1–9), along with two known analogues (10–11), were obtained from the aerial parts of Daphne penicillata.
A total synthesis of the unique sesquiterpene daphnepapytone A is described, using a bio-inspired strategy: after a method-oriented construction of the guaiane skeleton, a [2 + 2] cyclisation was followed by a highly selective late-stage oxidation.
This review summarizes the structural diversity, bioactivities, and biomimetic synthesis of [2 + 2]-type cyclobutane natural products, along with discussion of their biosynthesis, stereochemical analysis, racemic occurrence, and biomimetic synthesis.
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as alscholarine A from Alstonia scholaris.
Guided by MetGem Molecular Networking, eight daphnane-type and tigliane-type diterpenoids including four undescribed compounds were isolated from Daphne genkwa.