Nine undescribed carotane sesquiterpenes and rare rearranged guaiane sesquiterpenoids (1–9), along with two known analogues (10–11), were obtained from the aerial parts of Daphne penicillata.
A total synthesis of the unique sesquiterpene daphnepapytone A is described, using a bio-inspired strategy: after a method-oriented construction of the guaiane skeleton, a [2 + 2] cyclisation was followed by a highly selective late-stage oxidation.
This review summarizes the structural diversity, bioactivities, and biomimetic synthesis of [2 + 2]-type cyclobutane natural products, along with discussion of their biosynthesis, stereochemical analysis, racemic occurrence, and biomimetic synthesis.
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as alscholarine A from Alstonia scholaris.
This Highlight article describes a personal selection of recent misassigned structures of NPs and their revision with the aid of DU8ML, an ML-augmented DFT method for fast and accurate calculations of NMR parameters, mostly covering 2018 to 2025.