Employing unnatural promiscuity of sortase to construct peptide macrocycle libraries for ligand discovery

Yan-Ni Zhang, Xiao-Cui Wan, Yang Tang, Ying Chen, Feng-Hao Zheng, Zhi-Hui Cui, Hua Zhang, Zhaocai Zhou and Ge-Min Fang

Chem. Sci., 2024, 15, 9649
DOI: 10.1039/D4SC01992J

Polyfluorinated reagents for peptide stapling

Wanzhen Lin, Xin Ding, Jun-Wei Han, Li-Shuang Yu and Fa-Jie Chen

Org. Chem. Front., 2025, 12, 2777
DOI: 10.1039/D5QO00112A

Computational design of Bax-inhibiting peptides

Tom Vlaar, Bernadette Mayer, Lars van der Heide and Ioana M. Ilie

Mater. Adv., 2025, 6, 2160
DOI: 10.1039/D4MA01142B

Biocompatible synthesis of macrocyclic thiazole peptides from chiral α-amino nitriles

Minghao Shang, Junming He, Michael G. Gardiner and Christoph Nitsche

Org. Biomol. Chem., 2025
DOI: 10.1039/D4OB01989J

Non-symmetric cysteine stapling in native peptides and proteins

Sven Ullrich, Bishvanwesha Panda, Upamali Somathilake, Douglas J. Lawes and Christoph Nitsche

Chem. Commun., 2025, 61, 933
DOI: 10.1039/D4CC04995K

Charge-Enhanced Hydrogen Bond and Brønsted Acid Catalysis: An Evolving Frontier

Srini Vemulapalli, Brandon White, Nenad Kovljenic and Travis Dudding

Synthesis, 2025
DOI: 10.1055/a-2681-5829

Chemical and ribosomal synthesis of atropisomeric and macrocyclic peptides with embedded quinolines

Isaac J. Knudson, Taylor L. Dover, Diondra A. Dilworth, Cameron Paloutzian, Orel Paz, Jieye Lin, Hannah Cho, Tamir Gonen, Alanna Schepartz and Scott J. Miller

Nat. Chem., 2025
DOI: 10.1038/s41557-025-01935-4

Peptide therapeutics: current status and future opportunity with focus on nose-to-brain delivery☆

Eva-Maria Jülke and Annette G. Beck-Sickinger

Peptides, 2025, 188, 171404
DOI: 10.1016/j.peptides.2025.171404

Advancements in Loop Cyclization Approaches for Enhanced Peptide Therapeutics for Targeting Protein–Protein Interactions

Lucia Lombardi, Luke A. Granger, Robin J. Shattock and Daryl R. Williams

J. Org. Chem., 2025, 90, 1467
DOI: 10.1021/acs.joc.4c02178

Antimicrobial peptides: structure, functions and translational applications

Nelson G. Oliveira Júnior, Camila M. Souza, Danieli F. Buccini, Marlon H. Cardoso and Octávio L. Franco

Nat Rev Microbiol, 2025
DOI: 10.1038/s41579-025-01200-y

Macromolecular Function Emerging from Intramolecular Peptide Stapling of Synthetic Polymers

Henrik Kalmer, Federica Sbordone, John McMurtrie, Christoph Nitsche and Hendrik Frisch

Macromol. Rapid Commun., 2025, 46
DOI: 10.1002/marc.202400591

His-Tagging: Exploring Precise Chemical Modification of Histidine-Containing Bioactive Peptide Sequences

Sourav Chatterjee, Bishwajit Paul and Govindaswamy Shanker

Synlett, 2025, 36, 661
DOI: 10.1055/s-0043-1775364

From Concepts to Inhibitors: A Blueprint for Targeting Protein–Protein Interactions

Seong Ho Hong, Thu Nguyen, Joseph F. Ongkingco, Alex Nazzaro and Paramjit S. Arora

Chem. Rev., 2025, 125, 6819
DOI: 10.1021/acs.chemrev.5c00046

Cu-Catalyzed C–H Phenothiazination toward the Assembly of Cyclopeptides

Iván Pérez-Cubero, Paula Andrade-Sampedro, Ibon Sasiain and Arkaitz Correa

ACS Catal., 2025, 15, 10320
DOI: 10.1021/acscatal.5c02350

Non-symmetric stapling of native peptides

Fa-Jie Chen, Wanzhen Lin and Fen-Er Chen

Nat Rev Chem, 2024, 8, 304
DOI: 10.1038/s41570-024-00591-5

Peptide–Bismuth Tricycles: Maximizing Stability by Constraint

Lani J. Davies, Pritha Ghosh, Sauhta Siryer, Sven Ullrich and Christoph Nitsche

Chemistry A European J, 2025, 31
DOI: 10.1002/chem.202500064

Biocompatible Synthesis of Macrocyclic Thiazol(in)e Peptides

Junming He and Christoph Nitsche

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202401716

Synthesis and stability studies of constrained peptide–antimony bicycles

Sven Ullrich, Pritha Ghosh, Minghao Shang, Sauhta Siryer, Santhanalaxmi Kumaresan, Bishvanwesha Panda, Lani J. Davies, Upamali Somathilake, Abhishek P. Patel, Christoph Nitsche and Curt Wentrup

Aust. J. Chem., 2024, 77
DOI: 10.1071/CH24094

Regioselective Synthesis of Multiple Thioether-Bridged Peptides via a One-Pot Reaction

Nan Zhang, Meiqi Wu, Lijing Feng, Jiawei Wang, Ruotong Liang, Liangdong Zhao, Shigang Shen, Hua Chen, Tiesheng Shi and Shuying Huo

J. Org. Chem., 2025, 90, 12525
DOI: 10.1021/acs.joc.5c00733

The Potential of Peptide-Based Inhibitors in Disrupting Protein–Protein Interactions for Targeted Cancer Therapy

Alexandra L. Afonso, Catarina T. Cavaleiro, Miguel A. R. B. Castanho, Vera Neves and Marco Cavaco

IJMS, 2025, 26, 3117
DOI: 10.3390/ijms26073117

Diastereoselective Anomeric C(sp3)−H Cyclization Towards the Design of New Cyclophane‐Braced Glycopeptides

Sakna Bazzi, Ameni Hadj Mohamed, Dmytro Ryzhakov, Juba Ghouilem, Mehdi A. Beniddir, Vincent Gandon and Samir Messaoudi

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202418057

Screening macrocyclic peptide libraries by yeast display allows control of selection process and affinity ranking

Sara Linciano, Ylenia Mazzocato, Zhanna Romanyuk, Filippo Vascon, Lluc Farrera-Soler, Edward Will, Yuyu Xing, Shiyu Chen, Yoichi Kumada, Marta Simeoni, Alessandro Scarso, Laura Cendron, Christian Heinis and Alessandro Angelini

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-60907-x

Selection of Nucleotide-Encoded Mass Libraries of Macrocyclic Peptides for Inaccessible Drug Targets

Kilian Colas, Daniel Bindl and Hiroaki Suga

Chem. Rev., 2024, 124, 12213
DOI: 10.1021/acs.chemrev.4c00422

Phage-encoded bismuth bicycles enable instant access to targeted bioactive peptides

Sven Ullrich, Upamali Somathilake, Minghao Shang and Christoph Nitsche

Commun Chem, 2024, 7
DOI: 10.1038/s42004-024-01232-0

Diastereoselective Anomeric C(sp3)−H Cyclization Towards the Design of New Cyclophane‐Braced Glycopeptides

Sakna Bazzi, Ameni Hadj Mohamed, Dmytro Ryzhakov, Juba Ghouilem, Mehdi A. Beniddir, Vincent Gandon and Samir Messaoudi

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202418057