Cancer-on-a-chip for precision cancer medicine

Lunan Liu, Huishu Wang, Ruiqi Chen, Yujing Song, William Wei, David Baek, Mahan Gillin, Katsuo Kurabayashi and Weiqiang Chen

Lab Chip, 2025, 25, 3314
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Continuous flow delivery system for the perfusion of scaffold-based 3D cultures

Zachary R. Sitte, Elizabeth E. Karlsson, Haolin Li, Haibo Zhou and Matthew R. Lockett

Lab Chip, 2024, 24, 4105
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Selectively cross-linked hydrogel-based cocktail drug delivery micro-chip for colon cancer combinatorial drug screening using AI-CSR platform for precision medicine

Kiran Kaladharan, Chih-Hsuan Ouyang, Hsin-Yu Yang and Fan-Gang Tseng

Lab Chip, 2024, 24, 4766
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Convenient tumor 3D spheroid arrays manufacturing via acoustic excited bubbles for in situ drug screening

Jingjing Zheng, Xuejia Hu, Xiaoqi Gao, Yantong Liu, Shukun Zhao, Longfei Chen, Guoqing He, Jingwei Zhang, Lei Wei and Yi Yang

Lab Chip, 2023, 23, 1593
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Multi-step PDMS curing and a controlled separation method for mass manufacturing of high-performance and user-friendly micro-devices: valved micropumps

Zhichang Du, Wei Sun and Shengli Mi

Lab Chip, 2024, 24, 843
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A magnetically controlled microfluidic device for concentration dependent in vitro testing of anticancer drug

Vinit Kumar Yadav, Preetha Ganguly, Prashant Mishra, Samaresh Das and Dhiman Mallick

Lab Chip, 2023, 23, 4352
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AI-integrated microfluidics for drug screening: From single cell to organ-on-a-chip

Hongyun Yin, Zheyu Li, Zinuo Shen, Shiying Wang, Na Du, Shibo Cheng, Jie Zhou, Yutao Li, Yanwei Jia and Ying Li

Acta Pharmaceutica Sinica B, 2026, 16, 1175
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High-throughput combinatorial screening of antiplatelet drugs for personalized medicine

Chenguang Wang, Wenjie Zhu, Jiawei Zhu, Tian Gao, Zheyi Jiang, Tiantian Zhang, Long Chen, Junfeng Zhang, Yifan Liu and Alex Chia Yu Chang

Microsyst Nanoeng, 2026, 12
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Pressure-Free Assembling of Poly(methyl methacrylate) Microdevices via Microwave-Assisted Solvent Bonding and Its Biomedical Applications

Kieu The Loan Trinh, Woo Ri Chae and Nae Yoon Lee

Biosensors, 2021, 11, 526
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Touch-Enabled Reversible Microfluidic Ultradense Chips for Convenient, High-Throughput Electrochemical Assays

Pedro H. N. da Silva, Paula C. R. Corsato, Christian O. Silva, Gabriel J. C. Pimentel, Bruna M. Hryniewicz, Bruna Bragantin, Rodrigo S. Costa, Flávio M. Shimizu, Iris R. Sousa Ribeiro and Renato S. Lima

ACS Appl. Mater. Interfaces, 2025, 17, 45847
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Spheroid‐on‐a‐Chip Platforms for Tumor Microenvironment and Drug Development

Pierre Claver Uzabakiriho, Fan Jiajun, Benedictor Alexander Nguchu, Sajid Iqbal, Clarisse Manishimwe and Peter Shaw

Adv Materials Technologies, 2025, 10
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A High-Throughput and Logarithm-Serial-Dilution Microfluidic Chip for Combinational Drug Screening on Tumor Organoids

Xingyang Yan, Deng Tan, Lei Yu, DanYu Li, Wei Huang, Weiren Huang and Hongkai Wu

ACS Pharmacol. Transl. Sci., 2024, 7, 4135
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Microfluidic Devices: A Tool for Nanoparticle Synthesis and Performance Evaluation

Sara Gimondi, Helena Ferreira, Rui L. Reis and Nuno M. Neves

ACS Nano, 2023, 17, 14205
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Advances in microengineered platforms for 3D tumor production and modeling

Xufang Liu, Meilin Sun, Jinwei Zhang, Tingting Xuanyuan, Danyang Yu, Zheping Wang, Ying Wang, Zhenghao Deng and Wenming Liu

Biomed Microdevices, 2025, 27
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Combinatorial perturbation sequencing on single cells using microwell-based droplet random pairing

Run Xie, Yang Liu, Shiyu Wang, Xuyang Shi, Zhantao Zhao, Longqi Liu, Ya Liu and Zida Li

Biosensors and Bioelectronics, 2023, 220, 114913
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3D vascularized microphysiological system for investigation of tumor-endothelial crosstalk in anti-cancer drug resistance

Seunggyu Kim, Joonha Park, Jin-Nyoung Ho, Danhyo Kim, Sangchul Lee and Jessie S Jeon

Biofabrication, 2023, 15, 045016
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3D cell cultures toward quantitative high-throughput drug screening

Yichun Wang and Hyunsu Jeon

Trends in Pharmacological Sciences, 2022, 43, 569
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Switchable Electrode-Enabled High-Density Two-Dimensional Chips: A Simple, Generalizable Approach to Yield High-Throughput Electrochemical Analyses

Bruna M. Hryniewicz, Gabriela Zoia, Bruna Bragantin, Thiago S. Martins, Gabriel J. C. Pimentel, Juliana N. Y. Costa, Pedro H. N. da Silva, Paula C. R. Corsato, Karl J. Clinckspoor, Murilo Santhiago, Flávio M. Shimizu, Charles S. Henry, Osvaldo N. Oliveira and Renato S. Lima

ACS Sens., 2026, 11, 1137
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Engineering Osteosarcoma In Vitro: From Traditional Models to Biofabricated Platforms for Precision Medicine

Jing Liu, Bihan Ren, Tianma He, Dingming Li, Tao Ding, Qian Wang and Haochen Liu

ACS Omega, 2025, 10, 55219
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Surface Deformation of Biocompatible Materials: Recent Advances in Biological Applications

Sunhee Yoon, Ahmed Fuwad, Seorin Jeong, Hyeran Cho, Tae-Joon Jeon and Sun Min Kim

Biomimetics, 2024, 9, 395
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Microfluidics in High-Throughput Drug Screening: Organ-on-a-Chip and C. elegans-Based Innovations

Sunhee Yoon, Dilara Kilicarslan You, Uiechan Jeong, Mina Lee, Eunhye Kim, Tae-Joon Jeon and Sun Min Kim

Biosensors, 2024, 14, 55
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Advances in 3D Bioprinting and Microfluidics for Organ-on-a-Chip Platforms

Natan Roberto de Barros, Samarah Vargas Harb, Cintia Delai da Silva Horinouchi, Larissa Bueno Tofani, Daniela Mayra dos Santos, Giovanna Blazutti Elias, Julia Carnelos Machado Velho, Ana Carolina de Aguiar, Monielle Sant’Ana and Ana Carolina Migliorini Figueira

Polymers, 2025, 17, 3078
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Ultradense Electrochemical Chip and Machine Learning for High-Throughput, Accurate Anticancer Drug Screening

Daniel S. Doretto, Paula C. R. Corsato, Christian O. Silva, James C. Pessoa, Luis C. S. Vieira, William R. de Araújo, Flávio M. Shimizu, Maria H. O. Piazzetta, Angelo L. Gobbi, Iris R. S. Ribeiro and Renato S. Lima

ACS Sens., 2025, 10, 773
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On-Chip Prediction of Combination Drug Efficacy Using a Magnetofluidic Platform with Integrated Capacitive Sensors

Vinit Kumar Yadav, Preetha Ganguly, Samaresh Das, Prashant Mishra and Dhiman Mallick

ACS Appl. Mater. Interfaces, 2025, 17, 68882
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Construction and application of liver cancer models in vitro

Changmin Shao, Qingfei Zhang, Gaizhen Kuang, Qihui Fan and Fangfu Ye

Engineered Regeneration, 2022, 3, 310
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High-throughput solutions in tumor organoids: from culture to drug screening

Jianing Zuo, Yanhua Fang, Ruoyu Wang and Shanshan Liang

Stem Cells, 2025, 43
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Human organoids as 3D in vitro platforms for drug discovery: opportunities and challenges

Daisong Wang, Remi Villenave, Nadine Stokar-Regenscheit and Hans Clevers

Nat Rev Drug Discov, 2026, 25, 204
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