Issue 99, 2023

Redox-active ligand promoted electrophile addition at cobalt

Abstract

The reactivity of an electron-rich cobalt complex bearing an o-phenylenediamide ligand with electrophilic CF3+ and F+ sources is reported. These reactions lead to generation of a Co(III)–CF3 or Co(III)–F complex, promoted by redox-active ligand-to-substrate two-electron transfer. The rate of trifluoromethyl addition at cobalt correlates with the potential difference between the cobalt complex and the CF3+ source. We present initial demonstrations of radical trifluoromethylation and nucleophilic fluorination of organic substrates, setting the stage for the development of electrocatalytic pathways for these bond-forming reactions.

Graphical abstract: Redox-active ligand promoted electrophile addition at cobalt

Supplementary files

Article information

Article type
Communication
Submitted
30 Sept 2023
Accepted
16 Nov 2023
First published
17 Nov 2023

Chem. Commun., 2023,59, 14693-14696

Redox-active ligand promoted electrophile addition at cobalt

M. Zou and K. M. Waldie, Chem. Commun., 2023, 59, 14693 DOI: 10.1039/D3CC04869A

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