Issue 96, 2023

Concurrent Cu(ii)-initiated Fenton-like reaction and glutathione depletion to escalate chemodynamic therapy

Abstract

Chemodynamic therapy is an evolving therapeutic strategy but there are certain limitations associated with its treatment. Herein, we present de novo synthesis and mechanistic evaluation of HL1–HL8 ligands and their corresponding CuII(L1)2–CuII(L8)2. The most active Cu(L2)2 (IC50 = 5.3 μM, MCF-7) complex exclusively depletes glutathione while simultaneously promoting ROS production. Cu(L2)2 also affects other macromolecules like the mitochondrial membrane and DNA while activating the unfolded protein response cascade.

Graphical abstract: Concurrent Cu(ii)-initiated Fenton-like reaction and glutathione depletion to escalate chemodynamic therapy

Supplementary files

Article information

Article type
Communication
Submitted
12 Sept 2023
Accepted
25 Oct 2023
First published
27 Oct 2023

Chem. Commun., 2023,59, 14305-14308

Concurrent Cu(II)-initiated Fenton-like reaction and glutathione depletion to escalate chemodynamic therapy

A. Kumar, A. Chaudhary, B. Agrahari, K. Chaudhary, P. Kumar and R. G. Singh, Chem. Commun., 2023, 59, 14305 DOI: 10.1039/D3CC04519F

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