Issue 98, 2023

Lead-oriented synthesis of epigenetic relevant scaffolds

Abstract

A simple and rational method to rank lead-likeness of molecules using continuous evaluation functions was hereby developed. This strategy proved to be competitive against known methods and finally helped in driving synthetic efforts towards candidates of interest for epigenetic applications against HDAC6, BRD4 and EZH2.

Graphical abstract: Lead-oriented synthesis of epigenetic relevant scaffolds

Supplementary files

Article information

Article type
Communication
Submitted
31 Sext 2023
Accepted
14 Nov 2023
First published
15 Nov 2023

Chem. Commun., 2023,59, 14555-14558

Lead-oriented synthesis of epigenetic relevant scaffolds

T. Maujean, P. Kannaboina, A. I. Green and G. M. Burslem, Chem. Commun., 2023, 59, 14555 DOI: 10.1039/D3CC04317G

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