Issue 25, 2015

One-pot synthesis of doxorubicin-loaded multiresponsive nanogels based on hyperbranched polyglycerol

Abstract

Doxorubicin-loaded nanogels with multiresponsive properties are prepared using hyperbranched polyglycerol as a biocompatible scaffold. The nanogels are synthesized in a single step combining free-radical polymerization and a mild nanoprecipitation technique. The nanogels respond to different biological stimuli such as low pH and reductive environments, resulting in a more efficient cell proliferation inhibition in A549 cells.

Graphical abstract: One-pot synthesis of doxorubicin-loaded multiresponsive nanogels based on hyperbranched polyglycerol

Supplementary files

Article information

Article type
Communication
Submitted
22 Ian 2015
Accepted
02 Mar 2015
First published
02 Mar 2015

Chem. Commun., 2015,51, 5264-5267

Author version available

One-pot synthesis of doxorubicin-loaded multiresponsive nanogels based on hyperbranched polyglycerol

A. Sousa-Herves, S. Wedepohl and M. Calderón, Chem. Commun., 2015, 51, 5264 DOI: 10.1039/C5CC00644A

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