Issue 39, 2014

Multi-modal delivery of therapeutics using biomaterial scaffolds

Abstract

Functionalisation of biomaterials with therapeutic moieties (proteins, drugs, genes) is a pre-requisite to tissue regeneration and restoration of function following injury or disease. However, up until now, single-factor delivery has not proven to be clinically efficacious, most likely due to the complex nature of pathological states. In this regard, strategies that respect the complex nature of disease can prove successful, paving the way for the delivery of several factors to modulate several stages of the pathology over time. Biomaterials offer opportunities to deliver multiple therapeutics in a temporal manner (multi-modal release) using a number of strategies. The importance of these strategies will be described, as well as the methodologies used to achieve multi-modal release. Furthermore, strategies to engineer more programmed and responsive biomaterials as multi-modal delivery systems will be explored.

Graphical abstract: Multi-modal delivery of therapeutics using biomaterial scaffolds

Article information

Article type
Application
Submitted
28 Mai 2014
Accepted
07 Sext 2014
First published
07 Sext 2014

J. Mater. Chem. B, 2014,2, 6692-6707

Author version available

Multi-modal delivery of therapeutics using biomaterial scaffolds

S. Browne and A. Pandit, J. Mater. Chem. B, 2014, 2, 6692 DOI: 10.1039/C4TB00863D

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