Issue 38, 2014

Preparation, anti-trypanosomal activity and localisation of a series of dipeptide-based vinyl sulfones

Abstract

An improved, Weinreb amide-based, synthesis of anti-trypanosomal lysine-containing vinyl sulfones is described incorporating, as a feature, diversity at the ε-lysine amino group. Members of this family demonstrated moderate to good efficacy as anti-trypanosomal agents and a fluorescent dansyl (19) derivative was used to investigate subcellular localisation of the compound class.

Graphical abstract: Preparation, anti-trypanosomal activity and localisation of a series of dipeptide-based vinyl sulfones

Supplementary files

Article information

Article type
Paper
Submitted
07 Quint 2014
Accepted
12 Sext 2014
First published
12 Sext 2014

Org. Biomol. Chem., 2014,12, 7561-7571

Author version available

Preparation, anti-trypanosomal activity and localisation of a series of dipeptide-based vinyl sulfones

W. Doherty, J. James, P. Evans, L. Martin, N. Adler, D. Nolan and A. Knox, Org. Biomol. Chem., 2014, 12, 7561 DOI: 10.1039/C4OB01412J

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