Herein, we disclosed a convenient method for modular synthesis of structurally diverse sulfilimines through NFSI-mediated oxidative S-arylation of sulfenamides with naphthols, phenols and indoles at room temperature.
An S-selective and meta-regioselective arylation of sulfenamides with cyclic diaryl λ3-bromanes and λ3-chloranes under mild conditions has been exploited. It delivers S-aryl sulfilimines in good to excellent yields with high regioselectivity.
In this article, recent advances in catalytic asymmetric synthesis of chiral sulfilimines from sulfenamides via S–C bond formation are highlighted.
An efficient ring-opening sulfilimination of sulfonium salts with sulfenamides is developed for the construction of sulfur-containing alkyl sulfilimines.
An efficient Cu-catalyzed sulfilimine synthesis via aryl-, alkyl- and alkenylation of sulfenamides using readily accessible TT salts was developed. Mechanistic studies demonstrate the importance of EDA intermediates and bifunctional Cu catalyst.