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Chemistry of 2-vinylindoles: synthesis and applications

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New antiproliferative 3-substituted oxindoles inhibiting EGFR/VEGFR-2 and tubulin polymerization

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Novel 1,2,4-Triazole Derivatives Containing a Benzenesulfonamide Moiety as Potential Antifungal Agents for Controlling Postharvest Soft Rot in Kiwifruit

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Design, synthesis, biological assessment, and in-Silico studies of 1,2,4-triazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors

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Drug candidates and potential targets ofCurculigospp. compounds for treating diabetes mellitus based on network pharmacology, molecular docking and molecular dynamics simulation

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Synthesis and biological evaluation of novel dicarboxamide spirobibenzopyran derivatives with anticancer activity: In vitro selective cytotoxicity, induction of apoptosis and scratch assay

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Uracil as a Zn-Binding Bioisostere of the Allergic Benzenesulfonamide in the Design of Quinoline–Uracil Hybrids as Anticancer Carbonic Anhydrase Inhibitors

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Recent Insights in Multi‐Target Drugs in Pharmacology and Medicinal Chemistry

Sadık Hüseyin Cemali, Samet Poyraz, Samet Belveren, Senanur Taş, Mehmet Ali Tamer, Naciye Yaktubay Döndaş, H. Ali Döndaş and Jose Miguel Sansano

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Sulfonamides as anticancer agents: A brief review on sulfonamide derivatives as inhibitors of various proteins overexpressed in cancer

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Insight Study For Repurposing Of Certain Anti‐Inflammatory Drugs Based On Aspirin and Salicylic Acid Scaffolds For The Treatment of Cancer as CDKs Inhibitors: Cheminformatics and Anticancer Studies

Mohnad Abdalla, Ahmed E. Elmasry, Mohamed T. M. Nemr, Mohammed M. Alanazi, Nashwah G. M. Attallah and Yaseen A. A. M. Elshaier

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Investigation of pyridine-bearing thiazolidinone derivatives as promising inhibitors of thymidine phosphorylase and α-glucosidase: Theoretical and computational approaches to develop multitarget drugs

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Design, synthesis, modeling studies and biological evaluation of pyrazole derivatives linked to oxime and nitrate moieties as nitric oxide donor selective COX-2 and aromatase inhibitors with dual anti-inflammatory and anti-neoplastic activities

Wael A. A. Fadaly, Yaseen A. M. M. Elshaier, Mohamed T. M. Nemr and Khaled R. A. Abdellatif

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Discovery of new carbonic anhydrase IX inhibitors as anticancer agents by toning the hydrophobic and hydrophilic rims of the active site to encounter the dual-tail approach

Haytham O. Tawfik, Andrea Petreni, Claudiu T. Supuran and Mervat H. El-Hamamsy

European Journal of Medicinal Chemistry, 2022, 232, 114190
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Synthesis, Crystallographic, Quantum Chemical, Antitumor, and Molecular Docking/Dynamic Studies of 4-Hydroxycoumarin-Neurotransmitter Derivatives

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Synthesis, biological evaluation, and molecular docking study of thiophene‐, piperazine‐, and thiazolidinone‐based hybrids as potential antimicrobial agents

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Design, synthesis and cytotoxic evaluation of new thieno[2,3-d]pyrimidine analogues as VEGFR-2/AKT dual inhibitors, apoptosis and autophagy inducers

Heba K. Abd El-Mawgoud, Asmaa M. AboulMagd, Mohamed T.M. Nemr, Magdy M. Hemdan, Aya I. Hassaballah and Paula S. Farag

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Design, synthesis, antineoplastic activity of new pyrazolo[3,4-d]pyrimidine derivatives as dual CDK2/GSK3β kinase inhibitors; molecular docking study, and ADME prediction

Mohamed T.M. Nemr, Ahmed Elshewy, Mohammed L. Ibrahim, Ahmed M. El Kerdawy and Peter A. Halim

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Design, Synthesis, In Vivo Antimalarial Activity, and In Silico Studies of Sulfonamide‐Alkanamido Thiazole‐5‐Carboxylate Derivatives

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New 1,2,3-triazole/1,2,4-triazole hybrids linked to oxime moiety as nitric oxide donor selective COX-2, aromatase, B-RAF V600E and EGFR inhibitors celecoxib analogs: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis and molecular modeling study

Wael A. A. Fadaly, Mohamed T. M. Nemr, Taha H. Zidan, Fatma E. A. Mohamed, Marwa M. Abdelhakeem, Nour N. Abu Jayab, Hany A. Omar and Khaled R. A. Abdellatif

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Discovery of novel pyrazole based Urea/Thiourea derivatives as multiple targeting VEGFR-2, EGFRWT, EGFRT790M tyrosine kinases and COX-2 Inhibitors, with anti-cancer and anti-inflammatory activities

Wael A.A. Fadaly, Mohamed T.M. Nemr and Nesma M. Kahk

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Lipophilic Studies and In Silico ADME Profiling of Biologically Active 2-Aminothiazol-4(5H)-one Derivatives

Małgorzata Redka, Szymon Baumgart, Daria Kupczyk, Tomasz Kosmalski and Renata Studzińska

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Design, Synthesis, and Antioxidant and Anti-Tyrosinase Activities of (Z)-5-Benzylidene-2-(naphthalen-1-ylamino)thiazol-4(5H)-one Analogs: In Vitro and In Vivo Insights

Hee Jin Jung, Hye Jin Kim, Hyeon Seo Park, Hye Soo Park, Jeongin Ko, Dahye Yoon, Yujin Park, Pusoon Chun, Hae Young Chung and Hyung Ryong Moon

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Discovery of novel 4-trifluoromethyl-2-anilinoquinoline derivatives as potential anti-cancer agents targeting SGK1

Guangcan Xu, Lanlan Li, Mengfan Lv, Cheng Li, Jia Yu, Xiaoping Zeng, Xueling Meng, Gang Yu, Kun Liu, Sha Cheng, Heng Luo and Bixue Xu

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Novel HPLC method for pharmacokinetic study of new pioglitazone synthetic analogue: Greenness assessment

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Design and Synthesis of New pyrazole Hybrids Linked to Oxime and Nitrate Moieties as COX-2, EGFRL858R/T790M Inhibitors and Nitric Oxide Donors with dual Anti-inflammatory/Anti-proliferative Activities

Wael A.A. Fadaly, Mohamed T.M. Nemr, Abeer M. Abd El-Hameed, Fatma E.A. Mohamed and Taha H. Zidan

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Design and Discovery of New Dual Carbonic Anhydrase IX and VEGFR‐2 Inhibitors Based on the Benzenesulfonamide‐Bearing 4‐Thiazolidinones/2,4‐Thiazolidinediones Scaffold

Merve Zengin, Oya Unsal Tan, Suna Sabuncuoglu, Reem K. Arafa and Ayla Balkan

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Novel hydantoin derivatives: Synthesis and biological activity evaluation

Abdel Wahab Aqeel, Mahmoud A. Al-Sha'er, Rami Ayoub, Qais Jarrar and Mahmoud A. Alelaimat

Results in Chemistry, 2023, 6, 101118
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Current Scenario of Sulfonamide Hybrids with Anti-Breast Cancer Therapeutic Applications: I. Sulfonamide-Five-Membered Heterocycle Hybrids

Zhi Xu and Mengyu Ma

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New Chalcone Incorporated Structurally Modified Pyridine‐Pyrimidine Derivatives as Anticancer Agents: Their Design, Synthesis, and in‐vitro Evaluation

Swarupa Ketha, Chithaluri Sudhakar, Shashikala Kethireddy and Laxminarayana Eppakayala

Chemistry & Biodiversity, 2024, 21
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Discovery and optimization of 4-(imidazo[1,2-a]pyrimidin-3-yl)thiazol-2-amine derivatives as novel phosphodiesterase 4 inhibitors

Zongmin Wu, Furong Zhang, Zhexin Chen, Xue Wang, Xingfu Liu, Guofeng Yang, Sen Wang, Shuheng Huang, Hai-Bin Luo, Yi-You Huang and Deyan Wu

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Design, synthesis, docking, and anticancer evaluations of new thiazolo[3,2- a ] pyrimidines as topoisomerase II inhibitors

Mona S. El-Zoghbi, Samiha A. El-Sebaey, Hanan A. AL-Ghulikah and Eman A. Sobh

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, 38
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Synthesis, cytotoxic evaluation, and in silico studies of novel benzenesulfonamide-thiazolidinone derivatives against colorectal carcinoma

Belma Zengin Kurt, Mustafa Gökçe, Halil Şenol, Dilek Öztürk Civelek, Gülnur Dandin and Isil Gazioglu

Journal of Molecular Structure, 2025, 1321, 140153
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Novel benzenesulfonamide derivatives linked to diaryl pyrazole tail as potential carbonic anhydrase II/VII inhibitors with anti-epileptic activity

Wael A.A. Fadaly, Mohamed T.M. Nemr, Abeer M. Abd El-Hameed, Simone Giovannuzzi, Mahmoud Abdelrahman Alkabbani, Mohamed M. Hefina, Alessio Nocentini, Mamdouh F.A. Mohamed, Claudiu T. Supuran, Wagdy M. Eldehna and Taha H. Zidan

European Journal of Medicinal Chemistry, 2025, 291, 117619
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Preparation of 4-Arylthiazol-2(3H)-ones and the Three-Component Synthesis of Multidentate 5,5′-Methylenebis[4-arylthiazol-2(3H)-one] Ligands

Juan F. Ortuño, Samet Poyraz, Asmaa Belabbes, Özge Kavas, Samet Belveren, Cevher Altuğ, María de Gracia Retamosa, Francisco Foubelo, Christopher M. Pask, José M. Sansano and H. Ali Döndaş

Synthesis, 2023, 55, 141
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Endophytic Aspergillus sp. from Phragmites australis: A Source of DNA Gyrase Inhibitors with Antibiofilm, Antioxidant, and Cytotoxic Potentials: in vitro supported by in silico

Sarah I. Bukhari, Mosad A. Ghareeb, Maha Eid Omran, Omnia Karem M. Riad, Heba Mohammed Refat M. Selim, Ghadeer Bukhari, Nervana S. Diab, Maged M. Mahmoud, Nariman R. Soliman, Asmaa Saleh and Ahmed A. Hamed

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Chemistry of heterocycles as carbonic anhydrase inhibitors: A pathway to novel research in medicinal chemistry review

Anjaneyulu Bendi, Taruna, Rajni, Sweety Kataria, Lakhwinder Singh, John F. Kennedy, Claudiu T. Supuran and Neera Raghav

Archiv der Pharmazie, 2024, 357
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Recent development of azole–sulfonamide hybrids with the anticancer potential

Chenyuan Zhao, Yang Liu and Zhuo Cui

Future Medicinal Chemistry, 2024, 16, 1267
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Design, synthesis and evaluation of anticancer activity of new pyrazoline derivatives by down-regulation of VEGF: Molecular docking and apoptosis inducing activity

Rasha A. Hassan, Soha H. Emam, Dukhyun Hwang, Gun-Do Kim, Soha O. Hassanin, Mona G. Khalil, Amr M. Abdou and Amr Sonousi

Bioorganic Chemistry, 2022, 118, 105487
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Novel antiproliferative agents bearing substituted thieno[2,3-d]pyrimidine scaffold as dual VEGFR-2 and BRAF kinases inhibitors and apoptosis inducers; design, synthesis and molecular docking

Rasha A. Hassan, Mohammed I.A. Hamed, Amr M. Abdou and Yara El-Dash

Bioorganic Chemistry, 2022, 125, 105861
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Synthesis of Novel 2-(Cyclopentylamino)thiazol-4(5H)-one Derivatives with Potential Anticancer, Antioxidant, and 11β-HSD Inhibitory Activities

Szymon Baumgart, Daria Kupczyk, Aneta Archała, Oliwia Koszła, Przemysław Sołek, Wojciech Płaziński, Anita Płazińska and Renata Studzińska

IJMS, 2023, 24, 7252
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Design, synthesis, biological evaluation and docking analysis of pyrrolidine-benzenesulfonamides as carbonic anhydrase or acetylcholinesterase inhibitors and antimicrobial agents

Samet Poyraz, H. Ali Döndaş, Cem Yamali, Samet Belveren, Yeliz Demir, Sabriye Aydınoglu, Naciye Yaktubay Döndaş, Tugba Taskin-Tok, Senanur Taş, Mahmut Ülger and Jose M. Sansano

Journal of Biomolecular Structure and Dynamics, 2024, 42, 3441
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Spectroscopic, structural, and intermolecular interactions of 4-(2-hydroxy-3-methoxybenzylideneamino)-N-(5-methylisoxazol-3-yl)benzenesulfonamide enol-imine and keto-amine isomers

Hitler Louis, Goodness J. Ogunwale, Ernest C. Agwamba, Tomsmith O. Unimuke, Eze F. Ahuekwe and Adedapo S. Adeyinka

Journal of Molecular Structure, 2023, 1279, 134978
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New Multi-Targeted Antiproliferative Agents: Design and Synthesis of IC261-Based Oxindoles as Potential Tubulin, CK1 and EGFR Inhibitors

Momen R. Fareed, Mai E. Shoman, Mohammed I. A. Hamed, Mohamed Badr, Hanin A. Bogari, Sameh S. Elhady, Tarek S. Ibrahim, Gamal El-Din A. Abuo-Rahma and Taha F. S. Ali

Pharmaceuticals, 2021, 14, 1114
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New pyrazolyl-thiazolidinone/thiazole derivatives as celecoxib/dasatinib analogues with selective COX-2, HER-2 and EGFR inhibitory effects: design, synthesis, anti-inflammatory/anti-proliferative activities, apoptosis, molecular modelling and ADME studies

Wael A. A. Fadaly, Taha H. Zidan, Nesma M. Kahk, Fatma E. A. Mohamed, Marwa M. Abdelhakeem, Rehab G. Khalil and Mohamed T. M. Nemr

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, 38
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Novel thiazolone-benzenesulphonamide inhibitors of human and bacterial carbonic anhydrases

Morteza Abdoli, Viviana De Luca, Clemente Capasso, Claudiu T. Supuran and Raivis Žalubovskis

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, 38
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Comprehensive Insights Into Sulfanilamido‐Based Medicinal Design and Research

Yi‐Xin Wang, Juan Wang, Lin‐Li Mou, Hui‐Zhen Zhang, Guang‐Ying Chen and Cheng‐He Zhou

Medicinal Research Reviews, 2025
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Novel di-aryl chalcone derived pyrazole linked to methane sulfonyl pharmacophore as potent selective COX-2 inhibitors; design, synthesis, molecular modeling, in vitro and in vivo anti-inflammatory activities

Abeer M. Abd El-Hameed, Ahmed H. Lotfallah, Mohamed T. M. Nemr, Hoda Khalifa Abdelhady, Haredy Hassan Haredy, Ahmed M. Sayed, Mamdouh F. A. Mohamed, Deiaa E. Elsayed Abouzed and Wael A. A. Fadaly

Future Medicinal Chemistry, 2025, 17, 1849
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Design, synthesis and chemoinformatic studies of new thiazolopyrimidine derivatives as potent anticancer agents via phosphodiesterase-5 inhibition and apoptotic inducing activity

Mohamed T.M. Nemr, Mohamed Teleb, Asmaa M. AboulMagd, Mostafa E. El-Naggar, Noha Gouda, A.A. Abdel-Ghany and Yaseen A.M.M. Elshaier

Journal of Molecular Structure, 2023, 1272, 134216
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An overview on pharmaceutical applications of phosphodiesterase enzyme 5 (PDE5) inhibitors

Mohamed T. M. Nemr, Mostafa A. Abdelaziz, Mohamed Teleb, Ahmed E. Elmasry and Yaseen A. A. M. Elshaier

Mol Divers, 2024
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Assessing the pharmacological potential of selected xanthene derivatives

Anita Lazic, Aleksandra Masulovic, Jelena Ladjarevic and Natasa Valentic

J Serb Chem Soc, 2023, 88, 811
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Design, synthesis and biological evaluation of thienopyridine derivatives as c-Met kinase inhibitors

Tianyu Xie, Wenbo Hu, Lin You and Xin Wang

Mol Divers, 2025, 29, 2391
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Synthesis and Inhibition Activity Study of Triazinyl-Substituted Amino(alkyl)-benzenesulfonamide Conjugates with Polar and Hydrophobic Amino Acids as Inhibitors of Human Carbonic Anhydrases I, II, IV, IX, and XII

Mária Bodnár Mikulová, Dáša Kružlicová, Daniel Pecher, Andrea Petreni, Claudiu T. Supuran and Peter Mikuš

IJMS, 2021, 22, 11283
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Synthesis of novel multifunctional spirobibenzopyran derivatives: Crystal structure, In-silico study, anticancer activity and antimycobacterial activity

Meera Mori, Anjaliba Dodiya, Bhoomi Prajapati, Priyanka Mathur, Megha Chaudhari, Jayesh Sarvaiya, C. Ratna Prabha, Paritosh Shukla and Arpita Desai

Journal of Molecular Structure, 2025, 1345, 143033
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In-silico predicting as a tool to develop plant-based biomedicines and nanoparticles: Lycium shawii metabolites

Afrah E. Mohammed, Fuad Ameen, Kawther Aabed, Rasha Saad Suliman, Sahar Saleh Alghamdi, Fatmah Ahmed Safhi, Dalal Sulaiman Alshaya, Hayat Ali Alafari, Areej S. Jalal, Areej A. Alosaimi, Salha Mesfer Alshamrani and Ishrat Rahman

Biomedicine & Pharmacotherapy, 2022, 150, 113008
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Synthesis, antiproliferative activity, and molecular modeling of novel 4-methylcoumarin derivatives and/or nitric oxide donor hybrids

Malik Suliman Mohamed, Hany A. M. Elsherief, Hani Mohamed Hafez, Omar Awad Alsaidan, Samil I. Alzarea and Asmaa M. AboulMagd

Mol Divers, 2023, 27, 2133
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Synthesis, crystallographic, DNA binding, and molecular docking/dynamic studies of a privileged chalcone-sulfonamide hybrid scaffold as a promising anticancer agent

Moataz Shaldam, Haytham Tawfik, Heba Elmansi, Fathalla Belal, Koki Yamaguchi, Masaharu Sugiura and Galal Magdy

Journal of Biomolecular Structure and Dynamics, 2023, 41, 8876
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Novel guanidine derivatives targeting leukemia as selective Src/Abl dual inhibitors: Design, synthesis and anti-proliferative activity

Amr H. Moustafa, Asmaa M. AboulMagd, Ali M. Ali, Ahmed Khodairy, Adel A. Marzouk, Ayman Nafady and Mohamed T. M. Nemr

Bioorganic Chemistry, 2024, 147, 107410
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Novel benzenesulfonamide derivatives as potential selective carbonic anhydrase IX, XII inhibitors with anti-proliferative activity: Design, synthesis and in silico studies

Wael A.A. Fadaly, Fatma E.A. Mohamed, Mohamed T.M. Nemr, Ahmed M. Sayed, Rehab G. Khalil and Taha H. Zidan

Bioorganic Chemistry, 2024, 153, 107881
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Coumarin derivatives with potential anticancer and antibacterial activity: Design, synthesis, VEGFR‐2 and DNA gyrase inhibition, and in silico studies

Soha H. Emam, Rasha A. Hassan, Eman O. Osman, Mohammed I. A. Hamed, Amr M. Abdou, Mai M. Kandil, Eman Maher Elbaz and Demiana S. Mikhail

Drug Development Research, 2023, 84, 475
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Novel sulfonamide-tethered Schiff bases as anti-proliferative agents with VEGFR-2 inhibitory activity: Synthesis, biological assessment, and molecular dynamic simulations

Moataz A. Shaldam, Maha-Hamadien Abdulla, Andrea Angeli, Salma M. Hefny, Eman M. El-labbad, Abdullah Bin Obeed, Noura S. Alhassan, Claudiu T. Supuran, Wagdy M. Eldehna and Haytham O. Tawfik

Journal of Molecular Structure, 2024, 1309, 138148
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Development of novel amino-benzenesulfonamide derivatives and their analogues as carbonic anhydrase inhibitors: Design, synthesis, anticancer activity assessment, and pharmacokinetic studies using UPLC-MS/MS

Khaled A. Elsayad, Ghada F. Elmasry, Sally T. Mahmoud, Fadi M. Awadallah, Simone Giovannuzzi and Claudiu T. Supuran

Bioorganic Chemistry, 2025, 159, 108335
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