A responsive cascade drug delivery scaffold adapted to the therapeutic time window for peripheral nerve injury repair

Yizhu Shan, Lingling Xu, Xi Cui, Engui Wang, Fengying Jiang, Jiaxuan Li, Han Ouyang, Tailang Yin, Hongqing Feng, Dan Luo, Yan Zhang and Zhou Li

Mater. Horiz., 2024, 11, 1032
DOI: 10.1039/D3MH01511D

Combination of resveratrol and luteolin ameliorates α-naphthylisothiocyanate-induced cholestasis by regulating the bile acid homeostasis and suppressing oxidative stress

Wenying Wu, Kexin Li, Xiaohua Ran, Weiping Wang, Xiaolan Xu, Yu Zhang, Xiuyan Wei and Tianhong Zhang

Food Funct., 2022, 13, 7098
DOI: 10.1039/D2FO00521B

Profiling Class-Wide Bioactivities of Flavonoids While Minimizing Compound-Specific Effects Using an Equimolar Mixture Strategy

Alex Xiong Gao, Amy Xiao-Yang Wang, Zheng-Qi Wang, Mei-Xia Yang, Man-Man Sun, Farkhod Eshboev, Jin Gao, Tina Ting-Xia Dong and Karl Wah-Keung Tsim

J. Agric. Food Chem., 2025, 73, 28217
DOI: 10.1021/acs.jafc.5c09562

Luteolin, a common flavone in vegetables, acts as a hormetin possessing neurotrophic function: signaling mediated by inducing mitochondrial stress

Alex Xiong Gao, Tracy Chenxi Xia, Maggie Suisui Guo, Gary Kawing Yuen, Kevin Qiyun Wu, Tina Tingxia Dong and Karl Wah-Keung Tsim

Food Science and Human Wellness, 2025, 14, 9250035
DOI: 10.26599/FSHW.2024.9250035

Drug Screening of Flavonoids as Potential VEGF Inhibitors Through Computational Docking and Cell Models

Shengying Lin, Roy Wai-Lun Tang, Yutong Ye, Chenxi Xia, Jiahui Wu, Ran Duan, Ka-Wing Leung, Tina Ting-Xia Dong and Karl Wah-Keung Tsim

Molecules, 2025, 30, 257
DOI: 10.3390/molecules30020257

A Herbal Mixture of Sesami Semen Nigrum and Longan Arillus Induces Neurite Outgrowth in Cultured Neurons and Shows Anti-Depression in Chronic Mild Stress-Induced Rats

Alex Xiong Gao, Tracy Chen-Xi Xia, Marvin Shing-Hung Mak, Kevin Yue Zhu, Tina Ting-Xia Dong, Karl Wah-Keung Tsim and Md. Areeful Haque

Evidence-Based Complementary and Alternative Medicine, 2022, 2022, 1
DOI: 10.1155/2022/8809546

The ethanolic extract of peanut shell attenuates the depressive-like behaviors of mice through modulation of inflammation and gut microbiota

Alex Xiong Gao, Tracy Chen-Xi Xia, Zhi-Tian Peng, Qi-Yun Wu, Yue Zhu, Tina Ting-Xia Dong and Karl Wah-Keung Tsim

Food Research International, 2023, 168, 112765
DOI: 10.1016/j.foodres.2023.112765

Development of a novel LBL@DHBA/Cu-MOF coating on titanium implants to accelerate early osseointegration by promoting neural-vascular-bone coupling regeneration

Peng Hua, Xiaoyi Pan, Jiming Liu, Xuemei Chen, Manjuan Li, Yan Guo, Xuan Li, Pengyuan Leng, Guoyong Fan, Mengjiao Zheng, Kai Yu, Pingping Ma, Chi Zhang and Xinkun Shen

Chemical Engineering Journal, 2025, 514, 163246
DOI: 10.1016/j.cej.2025.163246

Research advances on CaMKs-mediated neurodevelopmental injury

Lingxu Kong, Jing Yang, Huajie Yang, Bin Xu, Tianyao Yang and Wei Liu

Arch Toxicol, 2024, 98, 3933
DOI: 10.1007/s00204-024-03865-5

MaR1 and NGF combine to inhibit autophagy through the GSK-3β/β-catenin pathway to promote sciatic nerve repair

Yuanhao Zhang, Shuang Zhao, Shaoni Wu, Haonan Niu, Lincong Gu and Youxin Song

J Transl Med, 2026, 24
DOI: 10.1186/s12967-026-07804-z

Luteolin attenuates cadmium neurotoxicity by suppressing glial inflammation and supporting neuronal survival

Hui-Yong Ma, Jing Wang, Jun Wang, Zhe Guo, Xiao-Yan Qin, Rongfeng Lan and Yang Hu

International Immunopharmacology, 2025, 152, 114406
DOI: 10.1016/j.intimp.2025.114406

Pterostilbene Potentiates the NGF-TrkA Signaling Pathway, Enhancing Differentiation in PC12 Cells

Dusadee Ospondpant, Xiong Gao, Shengying Lin, Yuen Man Ho, Tina Ting Xia Dong and Karl Wah Keung Tsim

J. Agric. Food Chem., 2025, 73, 9595
DOI: 10.1021/acs.jafc.4c10766

Nutritional assessment models for Alzheimer's disease: Advances and perspectives

Yuxi Wen, Lizhu Zhang, Na Li, Aijun Tong and Chao Zhao

Food Frontiers, 2023, 4, 624
DOI: 10.1002/fft2.216

Liensinine alleviates sepsis-induced acute liver injury by inhibiting the NF-κB and MAPK pathways in an Nrf2-dependent manner

Xiao Zhang, Silong Yuan, Hui Fan, Wei Zhang and Honggang Zhang

Chemico-Biological Interactions, 2024, 396, 111030
DOI: 10.1016/j.cbi.2024.111030

Bell's palsy was associated with TRPV2 downregulation of Schwann cell by cold stress

Yulan Bai, Weijiang Hao, Ziqi Zeng, Tiefeng Zhang, Wenjuan Zhang, Jing Yang, Feng Wu and Xianqi Li

Journal of Stomatology Oral and Maxillofacial Surgery, 2023, 124, 101533
DOI: 10.1016/j.jormas.2023.101533

The neurotrophic activities of brain‐derived neurotrophic factor are potentiated by binding with apigenin, a common flavone in vegetables, in stimulating the receptor signaling

Alex Xiong Gao, Tracy Chen‐Xi Xia, Lish Sheng‐Ying Lin, Tina Ting‐Xia Dong and Karl Wah‐Keung Tsim

CNS Neurosci Ther, 2023, 29, 2787
DOI: 10.1111/cns.14230

Role of natural plant extracts and hyaluronic acid derivatives in intranasal strategies for brain delivery. A review

K. Boualam, S. Scialla, I. Fasolino, T. Russo, E. Scarpa, N. De Cesare, V. Guarino, R. De Santis, M. Sobeh, N. Taarji, O. Abboussi, K. Taghzouti and U. D'Amora

International Journal of Biological Macromolecules, 2025, 315, 144636
DOI: 10.1016/j.ijbiomac.2025.144636

Bone mesenchymal stem cells attenuate axonopathy in spinal cord of rats exposed to 2,5-hexanedione via NGF-dependent and -independent pathways

Qiufang Bai, Zhe Li, Jing Chen, Man Liu, Xiaodan Shao, Xiaochi Chen, Fengyuan Piao and Linlin Fang

Mol Cell Biochem, 2026, 481, 1339
DOI: 10.1007/s11010-025-05466-x

Synergy of botanical drug extracts from Dracaena cochinchinensis stemwood and Ardisia elliptica fruit in multifunctional effects on neuroprotection and anti-inflammation

Dusadee Ospondpant, Queenie Wing Sze Lai, Tina Tingxia Dong and Karl Wah Keung Tsim

Front. Pharmacol., 2024, 15
DOI: 10.3389/fphar.2024.1399549

Flavonoids from Seabuckthorn (Hippophae rhamnoides L.) mimic neurotrophic functions in inducing neurite outgrowth in cultured neurons: Signaling via PI3K/Akt and ERK pathways

Chen-Xi Xia, Alex Xiong Gao, Tina Ting-Xia Dong and Karl Wah-Keung Tsim

Phytomedicine, 2023, 115, 154832
DOI: 10.1016/j.phymed.2023.154832

Neuro-Nutraceutical Polyphenols: How Far Are We?

Maria Teresa Gentile, Iolanda Camerino, Loredana Ciarmiello, Pasqualina Woodrow, Lidia Muscariello, Ida De Chiara and Severina Pacifico

Antioxidants, 2023, 12, 539
DOI: 10.3390/antiox12030539

Enhanced Anti-Hypoxia Efficacy of Morin via a ROS-Responsive Dextran-Based Nanodelivery System

Hang Gao, Nannan Jing, Yongkang Pan, Rui Li, Ting Wang, Xin Liu, Jiaqing Zhu and Jike Lu

Food Bioscience, 2026, 109030
DOI: 10.1016/j.fbio.2026.109030

Exploring the photophysical properties of flavone-based dyes as an anti-angiogenic agent and with fluorescence emission in the near-infrared (NIR) region: a TD-DFT study

H. Roohi and V. Pourghasem

Molecular Physics, 2024, 122
DOI: 10.1080/00268976.2024.2317451

Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression

Spandana Rajendra Kopalli, Tapan Behl, Ashishkumar Kyada, M.M. Rekha, Mayank Kundlas, Pooja Rani, Deepak Nathiya, K. Satyam Naidu, Monica Gulati, Manish Bhise, Priyanka Gupta, Pranay Wal, Mohammad Fareed, Seema Ramniwas, Sushruta Koppula and Amin Gasmi

Neuroscience, 2025, 569, 161
DOI: 10.1016/j.neuroscience.2025.02.007

Flavonoids Derived from Chinese Medicine: Potential Neuroprotective Agents

Jinhua Li, Ye Yu, Yanjie Zhang, Yilin Zhou, Shuxian Ding, Shuze Dong, Sainan Jin and Qin Li

Am. J. Chin. Med., 2024, 52, 1613
DOI: 10.1142/S0192415X24500630

The extract of peanut shell enhances neurite outgrowth of neuronal cells: Recycling of agricultural waste for development of nutraceutical products

Alex Xiong Gao, Jian Xiao, Tracy Chen-Xi Xia, Tina Ting-Xia Dong and Karl Wah-Keung Tsim

Journal of Functional Foods, 2022, 91, 105023
DOI: 10.1016/j.jff.2022.105023