Ameliorating effects of Hericium erinaceus polysaccharides on intestinal barrier injury in immunocompromised mice induced by cyclophosphamide

Baoming Tian, Peiyi Wang, Tianrui Xu, Ming Cai, Rongliang Mao, Liangshui Huang, Peilong Sun and Kai Yang

Food Funct., 2023, 14, 2921
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(−)-Epigallocatechin-3-gallate mitigates cyclophosphamide-induced intestinal injury by modulating the tight junctions, inflammation and dysbiosis in mice

Ran Wei, Xingquan Liu, Yuefei Wang, Junjie Dong, Fenghua Wu, Gerardo G. Mackenzie and Zhucheng Su

Food Funct., 2021, 12, 11671
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Microbiomics and metabolomics insights into the mechanism of egg yolk phosphatidylcholine enhancing intestinal immunity

Yunpeng Wen, Shuping Chen, Teng Wei, Na Wu, Yao Yao, Lilan Xu, Jihua Mao, Yan Zhao and Yonggang Tu

Food Funct., 2026, 17, 363
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Multi-dimensional immunoprotection of Ganoderma lucidum spore oil in immunosuppressed mice via microbiome-proteome-metabolome network analysis

Shuqi Deng, Xiaoxiao Wu, Wendong Xu, Xu Wu, Hongfei Cai, Shengpeng Wang, Juyan Liu and Jiliang Cao

Sci Rep, 2026, 16
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Yam protein ameliorates cyclophosphamide-induced intestinal immunosuppression by regulating gut microbiota and its metabolites

Jiahong Lu, Huacong Qin, Lili Liang, Jiaqi Fang, Kaiwen Hao, Yuting Song, Tianxia Sun, Ge Hui, Yunfei Xie and Yu Zhao

International Journal of Biological Macromolecules, 2024, 279, 135415
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Structure of a Pueraria root polysaccharide and its immunoregulatory activity on T and B lymphocytes, macrophages, and immunosuppressive mice

Gaofeng Cai, Caihong Wu, Tianyu Zhu, Song Peng, Shuwen Xu, Yuanliang Hu, Zhenguang Liu, Yang Yang and Deyun Wang

International Journal of Biological Macromolecules, 2023, 230, 123386
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Purification, structural characterization, and anti-ulcerative colitis activity of a novel pectin-like polysaccharide AH-H4–1 from Alhagi honey

Zhe Wang, Yaping Chi, Menghua Wang, Qianqian Zhou, Zexiang Yan, Rui Xue, Xiaoxia Cai, Jing Tian, Wei Yu, Saimijiang Yaermaimaiti, Chimengul Turghun, Yakun Sun, Wangdi Song, Daohai Du, Cheng Luo, Zelan Hu and Bo Han

International Journal of Biological Macromolecules, 2025, 319, 145432
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Structural characterization and immunomodulatory activity of polysaccharides from the lateral roots of Aconitum carmichaelii

Renbo Kou, Fuxin Mi, Cheng Peng, Xingjie Ding, Chunwang Meng, Fei Liu and Liang Xiong

International Journal of Biological Macromolecules, 2024, 282, 136935
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Glucan from Dictyophora rubrovolvata boosts immunity by regulating AKT‐STAT1 pathway to induce dendritic cells maturation and T cells differentiation

Yu Wu, Wengan Zhou, RuTing Feng, Duoduo Zhang, Yongkang Yu, Zuanyuan Huang, Junyi Yin, Xingtao Zhou and Shaoping Nie

Food Frontiers, 2023, 4, 1242
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Fucosylated chondroitin sulfate from sea cucumber Stichopus chloronotus alleviate the intestinal barrier injury and oxidative stress damage in vitro and in vivo

Huanan Yin, Rui Li, Jing Liu, Yanying Sun, Lei Zhao, Jiaojiao Mou and Jie Yang

Carbohydrate Polymers, 2024, 328, 121722
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Consumption of honey ameliorates lipopolysaccharide-induced intestinal barrier dysfunction via upregulation of tight junction proteins

Sandip Nathani, Neeladrisingha Das, Parul Katiyar, Bhairavnath Waghmode, Debabrata Sircar and Partha Roy

Eur J Nutr, 2023, 62, 3033
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Sciadonic acid ameliorates cyclophosphamide‐induced immunosuppression by modulating the immune response and altering the gut microbiota

Lin Chen, Qihong Jiang, Shiwei Yao, Chenkai Jiang, Hongling Lu, Wenjun Hu, Shaofang Yu, Mingqian Li, Yongcai Feng, Chin Ping Tan, Xingwei Xiang and Guoxin Shen

J Sci Food Agric, 2024, 104, 3902
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Network Pharmacology Study and Experimental Confirmation Revealing the Ameliorative Effects of Decursin on Chemotherapy-Induced Alopecia

Mi Hye Kim, Sang Jun Park and Woong Mo Yang

Pharmaceuticals, 2021, 14, 1150
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Isolation, purification and characterization of Pueraria lobata polysaccharide and its effects on intestinal function in cyclophosphamide-treated mice

Gaofeng Cai, Caihong Wu, Ningning Mao, Zuchen Song, Lin Yu, Tianyu Zhu, Song Peng, Yang Yang, Zhenguang Liu and Deyun Wang

International Journal of Biological Macromolecules, 2022, 218, 356
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Nondigestible stachyose alleviates cyclophosphamide-induced small intestinal mucosal injury in mice by regulating intestinal exosomal miRNAs, independently of the gut microbiota

Yuhang Hao, Chennan Wang, Lu Wang, Lili Hu, Tianchi Duan, Runguang Zhang, Xingbin Yang and Ting Li

Food Research International, 2025, 209, 116258
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The secretion of sIgA and dendritic cells activation in the intestinal of cyclophosphamide-induced immunosuppressed mice are regulated by Alhagi honey polysaccharides

Gaofeng Cai, Yang Yang, Pengfei Gu, Kui Li, Wusiman Adelijiang, Tianyu Zhu, Zhenguang Liu and Deyun Wang

Phytomedicine, 2022, 103, 154232
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Comparative analysis of the effects of cyclophosphamide and dexamethasone on intestinal immunity and microbiota in delayed hypersensitivity mice

Xiangling Li, Ruyan Wen, Ben Chen, Xia Luo, Lu Li, Jun Ai, Junlong Yu and Jordan Robin Yaron

PLoS ONE, 2024, 19, e0312147
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Raffinose reinforces the small intestinal barrier function through intestinal exosomal miRNA reprogramming

Yuhang Hao, Chennan Wang, Tianchi Duan, Lu Wang, Lili Hu, Xingbin Yang and Ting Li

Journal of Future Foods, 2026
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Antioxidant and Immunoprotective Effects of Moroccan Honey, Bee Pollen, and Propolis Against Cyclophosphamide‐Induced Immunosuppression in Mice: In Vitro, In Vivo, and In Silico Insights

Karima El‐yagoubi, Mohammed El ouassete, Najoua Soulo, Marouane Aouji, Soumaya Touzani and Badiaa Lyoussi

Journal of Food Science, 2026, 91
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Effects of different steaming times on the composition, structure and immune activity of Polygonatum Polysaccharide

Lian-lin Su, Xiaoman Li, Zhi-jun Guo, Xiao-yan Xiao, Peng Chen, Jiu-ba Zhang, Chun-qin Mao, De Ji, Jing Mao, Bo Gao and Tu-lin Lu

Journal of Ethnopharmacology, 2023, 310, 116351
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The structural characteristics of a pectic polysaccharide from Choerospondias axillaris fruit and its immunomodulatory effect on cyclophosphamide-induced immunosuppressed mice

Shiyi Xiong, Jinjiao Dong, Wenjun Wang, Guodong Zheng, Nansheng Wu, Jingjing Xie, Ruiling Wang, Xiaojin He and Jingen Li

International Journal of Biological Macromolecules, 2025, 308, 142575
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Simo decoction curing spleen deficiency constipation was associated with brain-bacteria-gut axis by intestinal mucosal microbiota

Xin Yi, Kang Zhou, Na Deng, Ying Cai, Xinxin Peng and Zhoujin Tan

Front. Microbiol., 2023, 14
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Potential Benefits of Egg White Proteins and Their Derived Peptides in the Regulation of the Intestinal Barrier and Gut Microbiota: A Comprehensive Review

Qi Yang, Siwen Lyu, Menglei Xu, Shengrao Li, Zhiyang Du, Xuanting Liu, Xiaomin Shang, Zhipeng Yu, Jingbo Liu and Ting Zhang

J. Agric. Food Chem., 2023, 71, 13168
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Melezitose inhibited glycolytic pathway and enhances anti-Crohn's disease activity via binding to PGK1

Miaomiao Zhang, Jianing Ma, Shulipan Mulati, Junmin Chang and Weiyi Zhang

Journal of Ethnopharmacology, 2025, 343, 119443
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Multiomics analysis revealed the immune-enhancement effects of xylooligosaccharides on cyclophosphamide-induced immunosuppression

Mengxue He, Jian Zhang, Fangzhou Liu, Yanwen Sun, Taile Li, Aichen Cai, Jiaxing Zhang, Wenli Jing, Jian Liu, Yuanfa Liu and Wei Yang

Food Bioscience, 2025, 73, 107580
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Effects of Alhagi camelorum Fisch polysaccharide from different regions on growth performance and gastrointestinal microbiota of sheep lambs

Zulikeyan Manafu, Zhenping Zhang, Xieraili Malajiang, Saifuding Abula, Qingyong Guo, Yi Wu, Adelijaing Wusiman and Batur Bake

Front. Pharmacol., 2024, 15
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Polysaccharides From the Roots of Millettia Speciosa Champ Modulate Gut Health and Ameliorate Cyclophosphamide-Induced Intestinal Injury and Immunosuppression

Xiaogang Chen, Wenjing Sun, Baichang Xu, Enyun Wu, Yao Cui, Kaiyuan Hao, Geyin Zhang, Congcong Zhou, Yanping Xu, Jiang Li and Hongbin Si

Front. Immunol., 2021, 12
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Mulberry leaf polysaccharide improves cyclophosphamide-induced growth inhibition and intestinal damage in chicks by modulating intestinal flora, enhancing immune regulation and antioxidant capacity

Ming Cheng, Yongbin Shi, Yumeng Cheng, Hongjie Hu, Song Liu, Yanping Xu, Lingzhi He, Shanshan Hu, Yujie Lu, Fengmin Chen, Jiang Li and Hongbin Si

Front. Microbiol., 2024, 15
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A study on the treatment effects of Crataegus pinnatifida polysaccharide on non-alcoholic fatty liver in mice by modulating gut microbiota

Ping Hao, Xiaonan Yang, Wen Yin, Xinyi Wang, Yun Ling, Mengyao Zhu, Yue Yu, Shouhai Chen, Yuan Yuan, Xiaoyu Quan, Zhiheng Xu, Jiahui Zhang, Wenjia Zhao, Ying Zhang, Chunlian Song, Qing Xu, Shuangshuang Qin, Yi Wu, Xianghua Shu and Kunhua Wei

Front. Vet. Sci., 2024, 11
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Cow Placenta Extract Ameliorates Cyclophosphamide-Induced Intestinal Damage by Enhancing the Intestinal Barrier, Improving Immune Function, and Restoring Intestinal Microbiota

Yuquan Zhao, Zeru Zhang, Anguo Tang, Zhi Zeng, Weijian Zheng, Yuxin Luo, Yixin Huang, Xinyi Dai, Wei Lu, Lei Fan and Liuhong Shen

Veterinary Sciences, 2024, 11, 505
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A polysaccharide from Alhagi honey protects the intestinal barrier and regulates the Nrf2/HO-1-TLR4/MAPK signaling pathway to treat alcoholic liver disease in mice

Jianzhong Song, Xin Zhao, Jiaqiang Bo, Zhiyuan Lv, Gairu Li, Yingying Chen, Jiaqi Liang, Chunyu Zhang, Xiaoyan Jin, Chang Liu and Junmin Chang

Journal of Ethnopharmacology, 2024, 321, 117552
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Bee Products and Colorectal Cancer—Active Components and Mechanism of Action

Justyna Moskwa, Sylwia Katarzyna Naliwajko, Dominika Dobiecka and Katarzyna Socha

Nutrients, 2023, 15, 1614
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Preventive effects of matrine on LPS-induced inflammation in RAW 264.7 cells and intestinal damage in mice through the TLR4/NF-κB/MAPK pathway

Ningning Mao, Yaming Yu, Xuanqi Lu, Yang Yang, Zhenguang Liu and Deyun Wang

International Immunopharmacology, 2024, 143, 113432
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Immunomodulation of exopolysaccharide produced by Lacticaseibacillus rhamnosus ZFM216 in cyclophosphamide-induced immunosuppressed mice by modulating gut microbiota

Liang Chen, Dong Wang, Wei Liu, Shaobo Zhou, Qing Gu and Tao Zhou

International Journal of Biological Macromolecules, 2024, 283, 137619
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Effects of Alhagi maurorum Medik polysaccharide derived from different regions on the intestinal immune functions of lambs

Zulikeyan Manafu, Ronglijiao Du, Xieraili Malajiang, Gulimire Abulikemu, Lijun Xue, Ayibike Bierdelieke, Yuan Xie, Dandan Liu, Zhanhai Mai, Qingyong Guo, Adelijiang Wusiman, Bin Li and Saifuding Abula

Front. Pharmacol., 2024, 15
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From Chemical Composition to Antiproliferative Effects Through In Vitro Studies: Honey, an Ancient and Modern Hot Topic Remedy

Alexandru Nan, Victor Dumitrascu, Corina Flangea, Gabi Dumitrescu, Daniela Puscasiu, Tania Vlad, Roxana Popescu and Cristian Vlad

Nutrients, 2025, 17, 1595
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Brain-bacteria-gut axis and oxidative stress mediated by intestinal mucosal microbiota might be an important mechanism for constipation in mice

Xin Yi, Kang Zhou, Ping Jiang, Na Deng, Xinxin Peng and Zhoujin Tan

3 Biotech, 2023, 13
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Structural Characterization and In Vitro Anti-Inflammatory Activity of Polysaccharides Isolated from the Fruits of Rosa laevigata

Song Peng, Pengfei Gu, Ningning Mao, Lin Yu, Tianyu Zhu, Jin He, Yang Yang, Zhenguang Liu and Deyun Wang

IJMS, 2024, 25, 2133
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Modulating the gut microbiota is involved in the effect of low-molecular-weight Glycyrrhiza polysaccharide on immune function

Wangdi Song, Yunyun Wang, Gongcheng Li, Shengnan Xue, Genlin Zhang, Yanyan Dang and Hebin Wang

Gut Microbes, 2023, 15
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Effects of Alhagi Honey Polysaccharides as Feed Supplement on Intestine Function and Microbiome, Immune Function, and Growth Performance in Chicken

Gaofeng Cai, Ningning Mao, Pengfei Gu, Tianyu Zhu, Jin He, Song Peng, Yang Yang, Zhenguang Liu, Yuanliang Hu and Deyun Wang

IJMS, 2022, 23, 14332
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Validated HPLC Analysis of Puerarin in Pueraria lobata–Derived Exosome‐Like Nanoparticles With Intestinal Barrier Enhancement

Junho Yu, Ji‐Hwan Yoon, Miey Park and Hae‐Jeung Lee

Journal of Food Science, 2025, 90
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Evaluation of the Effects of Euglena gracilis on Enhancing Immune Responses in RAW264.7 Cells and a Cyclophosphamide-Induced Mouse Model

Kyeong Ah Jo, Kyeong Jin Kim, Soo-yeon Park, Jin-Young Jeon, Ji Eun Hwang and Ji Yeon Kim

J. Microbiol. Biotechnol., 2023, 33, 493
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Rehmannia glutinosa polysaccharides alleviate cyclophosphamide-induced immunosuppression by enhancing immunity and restoring intestinal homeostasis

Lin Yu, Xiaofeng Shi, Xuanqi Lu, Xuping Zhao, Yaming Yu, Yushan Fang and Deyun Wang

International Journal of Biological Macromolecules, 2025, 311, 143692
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Preventive Mechanism of Lycopene on Intestinal Toxicity Caused by Cyclophosphamide Chemotherapy in Mice by Regulating TLR4-MyD88/TRIF-TRAF6 Signaling Pathway and Gut-Liver Axis

Xiao Pan, Xiaoyan Niu, Yaping Li, Yupei Yao and Lirong Han

Nutrients, 2022, 14, 4467
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Rehmannia glutinosa polysaccharides enhance intestinal immunity of mice through regulating the microbiota

Lin Yu, Fangzhu Lin, Yaming Yu, Xiangwen Deng, Xiaofeng Shi, Xuanqi Lu, Yu Lu and Deyun Wang

International Journal of Biological Macromolecules, 2024, 283, 137878
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Comparative Study of an Antioxidant Compound and Ethoxyquin on Feed Oxidative Stability and on Performance, Antioxidant Capacity, and Intestinal Health in Starter Broiler Chickens

Yong Xiao, Xuyang Gao and Jianmin Yuan

Antioxidants, 2024, 13, 1229
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Phytochemical composition, antioxidant activities and immunomodulatory effects of pigment extracts from Wugong Mountain purple red rice bran

Ting Chen, Hanyu Lu, Mingyue Shen, Qiang Yu, Yi Chen, Huiliang Wen and Jianhua Xie

Food Research International, 2022, 157, 111493
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Immuno-stimulatory activity of Astragalus polysaccharides in cyclophosphamide-induced immunosuppressed mice by regulating gut microbiota

Yanan Li, Junping Zheng, Yao Wang, Huabing Yang, Lu Cao, Shuiyong Gan, Jun Ma and Hongtao Liu

International Journal of Biological Macromolecules, 2023, 242, 124789
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Probiotic properties of Lacticaseibacillus paracasei MJ4 and its protective effect on mice with inflammatory bowel disease: A potential probiotic resource

Jianlong Lao, Junmei Li, Lin Tan, Shuping Yan, Zhaohai Wen, Yuan Qiu, Huiming Tan, Zengyuan Liu, Yanhong Yong, Xiaoxi Liu, Xingbin Ma, Xianghong Ju and Youquan Li

Journal of Functional Foods, 2025, 135, 107074
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Lacticaseibacillus casei IB1 Alleviates DSS-Induced Inflammatory Bowel Disease by Regulating the Microbiota and Restoring the Intestinal Epithelial Barrier

Jianlong Lao, Shuping Yan, Yanhong Yong, Yin Li, Zhaohai Wen, Xiaoyong Zhang, Xianghong Ju and Youquan Li

Microorganisms, 2024, 12, 1379
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Polysaccharides from Medicine and Food Homology Materials: A Review on Their Extraction, Purification, Structure, and Biological Activities

Jiaqi Xu, Jinling Zhang, Yumei Sang, Yaning Wei, Xingyue Chen, Yuanxin Wang and Hongkun Xue

Molecules, 2022, 27, 3215
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Purification, structural characterization, and bioactive properties of exopolysaccharides from Saccharomyces cerevisiae HD-01

Ruoxi Yang, Lina Liu, Dongni Gao and Dan Zhao

Front. Bioeng. Biotechnol., 2024, 12
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Polysaccharides from discarded tobacco leaves modulate immunity and ameliorate intestinal injury in cyclophosphamide‐treated mice

Ming Ma, Yingjie Li, Kunyan Chen, Changguo Wang, Lijun Zhu, Ji Ma and Qianfeng Chen

J Sci Food Agric, 2026, 106, 3289
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Alhagi honey polysaccharide ameliorates ulcerative colitis by modulating gut microbiota–tryptophan metabolism via AhR activation

Hang Yu, Jingmin Fan, Rui Xue, Jiawei Guan, Fangyuan Tian, Yu Xu, Linyun He, Ji Liu, Zhenzhu Du, Daqun Chen, Wei Yu, Wen Chen and Bo Han

Food Frontiers, 2024, 5, 1320
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Structure characterization and intestinal immune promotion effect of polysaccharide purified from Alhagi camelorum Fisch

Zulikeyan Manafu, Ronglijiao Du, Tuerhong Kudereti, Gulimire Abulikemu, Shakeel Ahmed Lakho, Lijun Xue, Ayibike Bierdelieke, Faiz Muhammad Khand, Ambreen Leghari, Yuan Xie, Saifuding Abula, Bateer Bake, Qingyong Guo and Adelijiang Wusiman

International Journal of Biological Macromolecules, 2024, 269, 132077
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Digestion of pectic polysaccharide from Brassica rapa L. in vitro and its effect on the intestinal microbiota in cyclophosphamide‐treated mice

Wei Wang, Lijun Fan, Xuewen Li, Zirong Wang, Jianzhong Zhou, Buligen Jialengbieke, Jianye Ren and Xiaodong Hu

Int J of Food Sci Tech, 2022, 57, 92
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