Issue 79, 2018
From the journal:

Chemical Communications

Active targeted drug delivery of MMP-2 sensitive polymeric nanoparticles†

Jie Pan, ORCID logo *a   Pei-Jiao Li,ab   Yi Wang,b   Lu Chang,a   Dong Wan*a  and  Hao Wang ORCID logo *b  

* Corresponding authors

a School of Environmental and Chemical Engineering, Tianjin Polytechnic University, Tianjin 300387, P. R. China
E-mail: panjie@tjpu.edu.cn, wandong_tjpu@126.com

b CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, P. R. China
E-mail: wanghao@nanoctr.cn

Abstract

Novel matrix metalloproteinase 2 (MMP2)-sensitive nanoparticles (NPs) are developed with copolymers of TPGS3350-pp-PLGA and TPGS-folate to overcome some drawbacks of traditional anticancer formulations in drug delivery, such as short circulation time in blood, small drug accumulation at the tumor site, low intracellular uptake, etc.

Graphical abstract: Active targeted drug delivery of MMP-2 sensitive polymeric nanoparticles

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Article information

DOI
https://doi.org/10.1039/C8CC05504A
Article type
Communication
Submitted
09 Jul 2018
Accepted
28 Aug 2018
First published
29 Aug 2018

Chem. Commun., 2018,54, 11092-11095

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Active targeted drug delivery of MMP-2 sensitive polymeric nanoparticles

J. Pan, P. Li, Y. Wang, L. Chang, D. Wan and H. Wang, Chem. Commun., 2018, 54, 11092 DOI: 10.1039/C8CC05504A

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