Issue 29, 2013
From the journal:

Chemical Communications

Autofluorescence generation and elimination: a lesson from glutaraldehyde†

Kwahun Lee,‡a   Sungmoon Choi,‡a   Chun Yang,b   Hai-Chen Wub  and  Junhua Yu*a  

* Corresponding authors

a Department of Chemistry Education, Seoul National University, 1 Gwanak-Ro, Gwanak-Gu, Seoul 151-742, South Korea
E-mail: junhua@snu.ac.kr
Fax: +82-2-889-0749
Tel: +82-2-880-9159

b Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China

Abstract

Glutaraldehyde causes especially high autofluorescence. It reacted with proteins and peptides to generate visible to near-IR emitters. A model indicated that ethylenediamine and a secondary amine in the molecule were key components for the formation of emissive species. The mechanism enables us to control the generation and elimination of autofluorescence.

Graphical abstract: Autofluorescence generation and elimination: a lesson from glutaraldehyde

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Article information

DOI
https://doi.org/10.1039/C3CC40799C
Article type
Communication
Submitted
30 Jan 2013
Accepted
26 Feb 2013
First published
26 Feb 2013

Chem. Commun., 2013,49, 3028-3030

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Autofluorescence generation and elimination: a lesson from glutaraldehyde

K. Lee, S. Choi, C. Yang, H. Wu and J. Yu, Chem. Commun., 2013, 49, 3028 DOI: 10.1039/C3CC40799C

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