Issue 77, 2013
From the journal:

Chemical Communications

Cinchonine and thiourea

Yumeng Xia  and  Xiaodong Shi*a  

* Corresponding authors

a C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia 26505, USA
E-mail: Xiaodong.Shi@mail.wvu.edu
Fax: +1-304-293-4904
Tel: +1-304-293-0179

Abstract

In this viewpoint, we discuss the seminal work contributed by Dixon, who reported the first use of a bifunctional cinchona-derived thiourea organocatalyst for the enantioselective conjugate addition of malonate esters to nitroalkenes. Since then, this class of catalysts has been extensively utilized in a variety of fundamental transformations. We also highlight here some of the representative studies performed since the publication of this milestone work in 2005.

Graphical abstract: Cinchonine and thiourea

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Article information

DOI
https://doi.org/10.1039/C3CC40825F
Article type
Viewpoint
Submitted
31 Jan 2013
Accepted
30 Jul 2013
First published
31 Jul 2013

Chem. Commun., 2013,49, 8583-8585

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Cinchonine and thiourea

Y. Xi and X. Shi, Chem. Commun., 2013, 49, 8583 DOI: 10.1039/C3CC40825F

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