Issue 29, 2024

Encapsulation of luminol and Co2+ within a metal–organic framework for enhanced chemiluminescence and imaging of inflammation

Abstract

Chemiluminescence can eliminate interference caused by excitation light sources, thereby providing ultrasensitive imaging for the detection of various diseases. In this work, we report a novel chemiluminescent system by encapsulating luminol and Co2+ within a metal–organic framework (MOF) UiO-67-bpydc. Due to the chelation of the Co2+ on the N-site from the ligand as well as the confinement of luminol within the pores of UiO-67-bpydc, the synthesized MOF composite UiO-67-bpydc⊃Co+Lu exhibits significantly enhanced chemiluminescence intensity, which is 8300 times higher than that of luminol. The potential practical application of UiO-67-bpydc⊃Co+Lu was also evaluated by the quantitative analysis of H2O2 and glucose. The results indicate that the H2O2 and glucose could be linearly detected over the range from 10 to 100 μM with a detection limit of 0.52 μM and 10 to 400 of μM with a detection limit of 1.36 μM, respectively. By taking advantage of the sensitive sensing properties and excellent biocompatibility, chemiluminescence imaging of skin inflammation in mice was demonstrated utilizing UiO-67-bpydc⊃Co+Lu. This work provides inspiration to design highly emissive chemiluminescent materials for use in diagnosis.

Graphical abstract: Encapsulation of luminol and Co2+ within a metal–organic framework for enhanced chemiluminescence and imaging of inflammation

Supplementary files

Article information

Article type
Paper
Submitted
04 میٔ 2024
Accepted
16 جوٗن 2024
First published
17 جوٗن 2024

J. Mater. Chem. C, 2024,12, 11012-11019

Encapsulation of luminol and Co2+ within a metal–organic framework for enhanced chemiluminescence and imaging of inflammation

H. Chen, D. Zou, W. Cao, Y. Cui, G. Qian and Z. Liao, J. Mater. Chem. C, 2024, 12, 11012 DOI: 10.1039/D4TC01826E

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