Ni-Catalyzed Reductive Cyanation of Alkenyl Tosylates and Triflates

Abstract

Herein, we disclose the nickel-catalyzed reductive cyanation of alkenyl tosylates and triflates. Both cyclic and acyclic alkenyl nitriles are produced in moderate to good yield using 2-(4-methoxyphenyl)-2-methylmalononitrile (MeO-MPMN), a novel transnitrilation, or nitrile transfer, reagent. A robustness screen was undertaken to demonstrate the functional group tolerance of this method.

Supplementary files

Article information

Article type
Communication
Submitted
25 ستمبر 2024
Accepted
30 اکتوٗبر 2024
First published
31 اکتوٗبر 2024

Chem. Commun., 2024, Accepted Manuscript

Ni-Catalyzed Reductive Cyanation of Alkenyl Tosylates and Triflates

J. Graham and S. Rousseaux, Chem. Commun., 2024, Accepted Manuscript , DOI: 10.1039/D4CC04972A

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