Issue 3, 2015

Novel strategies for catalytic asymmetric synthesis of C1-chiral 1,2,3,4-tetrahydroisoquinolines and 3,4-dihydrotetrahydroisoquinolines

Abstract

1,2,3,4-Tetrahydroisoquinoline is one of the most important “privileged scaffolds” present in natural products. C1-chiral tetrahydroisoquinolines have exhibited a wide variety of bioactivities and found applications as chiral scaffolds in asymmetric catalysis. This paper summarizes novel catalytic stereoselective strategies that emerged in the last ten years for synthesis of 1,2,3,4-tetrahydroisoquinoline and 3,4-dihydroisoquinoline scaffolds, beyond the traditional Pictet–Spengler and related protocols, as well as their applications in the total synthesis of alkaloid natural products.

Graphical abstract: Novel strategies for catalytic asymmetric synthesis of C1-chiral 1,2,3,4-tetrahydroisoquinolines and 3,4-dihydrotetrahydroisoquinolines

Associated articles

Article information

Article type
Review Article
Submitted
08 نومبر 2014
Accepted
14 دسمبر 2014
First published
16 دسمبر 2014

Org. Chem. Front., 2015,2, 288-299

Author version available

Novel strategies for catalytic asymmetric synthesis of C1-chiral 1,2,3,4-tetrahydroisoquinolines and 3,4-dihydrotetrahydroisoquinolines

W. Liu, S. Liu, R. Jin, H. Guo and J. Zhao, Org. Chem. Front., 2015, 2, 288 DOI: 10.1039/C4QO00294F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements