Tuneable redox-responsive albumin-hitchhiking drug delivery to tumours for cancer treatment

Shiwei Fu; Ajay Zheng; Lukun Wang; Jiuyan Chen; Bowen Zhao; Xiao Zhang; Victoria A. A. McKenzie; Zixin Yang; Roger M. Leblanc; Rajeev Prabhakar; Fuwu Zhang

doi:10.1039/D4TB00751D

Tuneable redox-responsive albumin-hitchhiking drug delivery to tumours for cancer treatment†

Shiwei Fu,^a Ajay Zheng,

^a Lukun Wang,^a Jiuyan Chen,^a Bowen Zhao,^a Xiao Zhang,

^a Victoria A. A. McKenzie,^a Zixin Yang,^a Roger M. Leblanc,

^a Rajeev Prabhakar

^a and Fuwu Zhang

*^ab

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Miami, Coral Gables, FL 33146, USA
E-mail: fxz174@miami.edu

^b The Dr John T. Macdonald Foundation Biomedical Nanotechnology Institute, University of Miami, Miami, FL 33136, USA

Abstract

This paper outlines a novel drug delivery system for highly cytotoxic mertansine (DM1) by conjugating to an albumin-binding Evans blue (EB) moiety through a tuneable responsive disulfide linker, providing valuable insights for the development of effective drug delivery systems toward cancer therapy.

This article is part of the themed collections: Journal of Materials Chemistry B HOT Papers and Journal of Materials Chemistry B Emerging Investigators 2024

Journal of Materials Chemistry B

Tuneable redox-responsive albumin-hitchhiking drug delivery to tumours for cancer treatment†

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Tuneable redox-responsive albumin-hitchhiking drug delivery to tumours for cancer treatment

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