Nitroenediamines (EDAMs), and N-methyl-1-(methylthio)-2-nitroethenamine (NMSM) derivatives: scaffolds for heterocycle molecular diversity (update from 2012 to 2021)

Abstract

Nitro-1,1-enediamines (EDAMs) and 1,1-bis(methylthio)-2-nitroethene (NMSN) have proven to be a class of attractive and useful synthetic building blocks for use in the synthesis of heterocyclic and fused heterocyclic compounds. The bicyclic or tricyclic heterocycles derived from these frames widely exist in natural and synthetic drugs. To comprehend the reaction properties of EDAMs and NMSN and to design other novel fused heterocycles with biological effects in the future, it is essential to investigate their recent reactions. The current review envisions highlighting some recent and remarkable examples of nitroenediamine reactions categorized by catalyst-assisted and catalyst-free reactions from 2012 onward.