Issue 23, 2022

Hybridization-specific chemical reactions to create interstrand crosslinking and threaded structures of nucleic acids

Abstract

The interstrand crosslinking and threaded structures of nucleic acids have high potential in oligonucleotide therapeutics, chemical biology, and nanotechnology. For example, properly designed crosslinking structures provide high activity and nuclease resistance for anti-miRNAs. The noncovalent labeling and modification by the threaded structures are useful as new chemical biology tools. Photoreversible crosslinking creates smart materials, such as reversible photoresponsive gels and DNA origami objects. This review introduces the creation of interstrand crosslinking and threaded structures, such as catenanes and rotaxanes, based on hybridization-specific chemical reactions and their functions and perspectives.

Graphical abstract: Hybridization-specific chemical reactions to create interstrand crosslinking and threaded structures of nucleic acids

Article information

Article type
Review Article
Submitted
23 مارٕچ 2022
Accepted
18 میٔ 2022
First published
19 میٔ 2022

Org. Biomol. Chem., 2022,20, 4699-4708

Author version available

Hybridization-specific chemical reactions to create interstrand crosslinking and threaded structures of nucleic acids

K. Onizuka, Y. Yamano, A. M. Abdelhady and F. Nagatsugi, Org. Biomol. Chem., 2022, 20, 4699 DOI: 10.1039/D2OB00551D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements