Issue 15, 2022

Practical synthesis of quinolone drugs via a novel TsCl-mediated domino reaction sequence

Abstract

A novel TsCl-mediated domino sequence to expeditiously access quinolone-based antibiotics, such as ciprofloxacin, norfloxacin, pefloxacin, oxilinic acid, ivacaftor and the precursor of grepftfloxacin and ozenoxacin, starting from commercially available chromone-3-carboxaldehydes and amines, was developed. The total synthesis of these quinolone-based drugs via this sequence shortens the original seven/eight step synthesis to three/four steps with a high overall yield under environmentally benign conditions. The quinolone-based antibiotic drug analogues could also be efficiently synthesized by varying the starting materials and chemical reagents for discovering and developing new antibiotics.

Graphical abstract: Practical synthesis of quinolone drugs via a novel TsCl-mediated domino reaction sequence

Supplementary files

Article information

Article type
Communication
Submitted
06 میٔ 2022
Accepted
15 جوٗن 2022
First published
08 جوٗلایی 2022

Green Chem., 2022,24, 5755-5759

Practical synthesis of quinolone drugs via a novel TsCl-mediated domino reaction sequence

J. Lei, Y. Ding, H. Zhou, X. Gao, Y. Cao, D. Tang, H. Li, Z. Xu and Z. Chen, Green Chem., 2022, 24, 5755 DOI: 10.1039/D2GC01689C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements