Photofunctional cyclometallated iridium(III) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications

Lili Huang; Peter Kam-Keung Leung; Lawrence Cho-Cheung Lee; Guang-Xi Xu; Yun-Wah Lam; Kenneth Kam-Wing Lo

doi:10.1039/D2CC02405E

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Photofunctional cyclometallated iridium(iii) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications†

Lili Huang,

^a Peter Kam-Keung Leung,

^ab Lawrence Cho-Cheung Lee,

^ac Guang-Xi Xu,

^a Yun-Wah Lam

*^a and Kenneth Kam-Wing Lo

*^ab

Author affiliations

* Corresponding authors

^a Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Hong Kong, P. R. China
E-mail: bhkenlo@cityu.edu.hk

^b State Key Laboratory of Terahertz and Millimetre Waves, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P. R. China

^c Laboratory for Synthetic Chemistry and Chemical Biology Limited, Units 1503 – 1511, 15/F, Building 17W, Hong Kong Science Park, New Territories, Hong Kong, P. R. China

Abstract

We report herein near-infrared (NIR)-emitting cyclometallated iridium(III) complexes bearing a heteroaromatic methylsulfone moiety as sulfhydryl-specific reagents; one of the complexes was conjugated to cysteine and cysteine-containing peptides and proteins for bioimaging and photocytotoxic applications.

This article is part of the themed collection: Celebrating 10 years of ChemComm Emerging Investigators

Download options Please wait...

Supplementary files

Supplementary information PDF (4748K)

Article information

DOI: https://doi.org/10.1039/D2CC02405E
Article type: Communication
Submitted: 28 اپریل 2022
Accepted: 05 اگست 2022
First published: 08 اگست 2022

Download Citation

Chem. Commun., 2022,58, 10162-10165

Permissions

Request permissions

Photofunctional cyclometallated iridium(III) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications

L. Huang, P. K. Leung, L. C. Lee, G. Xu, Y. Lam and K. K. Lo, Chem. Commun., 2022, 58, 10162 DOI: 10.1039/D2CC02405E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications

Photofunctional cyclometallated iridium(iii) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Photofunctional cyclometallated iridium(III) polypyridine methylsulfone complexes as sulfhydryl-specific reagents for bioconjugation, bioimaging and photocytotoxic applications

Social activity

Search articles by author

Spotlight

Advertisements