Issue 5, 2022

A theranostic microneedle array patch for integrated glycemia sensing and self-regulated release of insulin

Abstract

Diabetes can cause various complications and affect the normal functioning of the human body. A theranostic and diagnostic platform for real-time glycemia sensing and simultaneous self-regulated release of insulin is desired to improve diabetic patients’ life quality. Here, we describe a theranostic microneedle array patch, which enables the achievement of visualization quantification of glycemia and simultaneously self-regulated release of insulin. The microneedle patch (MNDF) was fabricated by crosslinking of 3-aminophenylboronic acid (ABA)-modified sodium alginate and chondroitin sulfate. The hierarchical structure consisted of a tip part containing mineralized insulin particles and glucose oxidase (GOD) for insulin release, and a base surface embodying 3,3′,5,5′-tetramethylbenzidine (TMB) and (horseradish peroxidase) HRP for real-time glycemia sensing. In the presence of glucose, GOD converts glucose into H+ and H2O2, driving gradual dissolution of the calcium layer of insulin particles, resulting in long-acting release of insulin. By the bio-catalytic action of HRP, the generated H2O2 brings about a visible color change allowing the glucose level at the base surface to be read out. We believe that the theranostic microneedle array patch can act as a promising alternative for future clinical applications.

Graphical abstract: A theranostic microneedle array patch for integrated glycemia sensing and self-regulated release of insulin

Supplementary files

Article information

Article type
Paper
Submitted
30 نومبر 2021
Accepted
16 جنؤری 2022
First published
20 جنؤری 2022

Biomater. Sci., 2022,10, 1209-1216

A theranostic microneedle array patch for integrated glycemia sensing and self-regulated release of insulin

X. Sun, W. Ji, B. Zhang, L. Ma, W. Fu, W. Qian, X. Zhang, J. Li, E. Sheng, Y. Tao and D. Zhu, Biomater. Sci., 2022, 10, 1209 DOI: 10.1039/D1BM01834E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements