Copper-catalyzed redox-neutral regioselective chlorosulfonylation of vinylarenes

Abstract

A copper-catalyzed redox-neutral, regioselective aromatic alkene chlorosulfonylation reaction has been developed. This protocol features simple procedure, easily accessible materials and good functional group tolerance. Moreover, it could be amplified to a gram scale and smoothly applied to the late-stage modification of bioactive molecule derivatives.