A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent†
Silvia
Anselmi, 
a
Siyu
Liu,
a
Seong-Heun
Kim,
a
Sarah M.
Barry,
b
Thomas S.
Moody
*cd
and
Daniele
Castagnolo
*a
a
Siyu
Liu,
a
Seong-Heun
Kim,
a
Sarah M.
Barry,
b
Thomas S.
Moody
*cd
and
Daniele
Castagnolo
*a
Abstract
A mild, chemoselective and sustainable biocatalysed synthesis of sulfoxides has been developed exploiting CALB and using AcOEt with a dual role of more environmentally friendly reaction solvent and enzyme substrate. A series of sulfoxides, including the drug omeprazole, have been synthesised in high yields and with excellent E-factors.
- This article is part of the themed collections: Biocatalysis: A cross-journal collection and Catalysis & biocatalysis in OBC
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