Acridinium benzoates for ratiometric fluorescence imaging of cellular viscosity

Min Wen; Chen Li; Mengyuan Zhang; Yan Sun; Fengming Liu; Xiaoyan Cui; Yongkui Shan

doi:10.1039/D0AN02321C

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Acridinium benzoates for ratiometric fluorescence imaging of cellular viscosity†

Min Wen,^a Chen Li,^a Mengyuan Zhang,^a Yan Sun,^a Fengming Liu,^b Xiaoyan Cui

*^a and Yongkui Shan^a

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* Corresponding authors

^a Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, P.R. China
E-mail: xycui@chem.ecnu.edu.cn

^b National Center for Protein Science Shanghai, No.333 Haike Road, Pudong New District, Shanghai 200120, China

Abstract

A series of fluorescent molecular rotors, acridinium benzoates (Acr-A,B,C,D), were designed for ratiometrically monitoring cellular viscosity. High sensitivity to viscosity was observed in probe Acr-A with an insignificant steric effect in the acridinium nitrogen. Acr-A was employed to distinguish cancer cells from normal cells and track the dynamics of viscosity during cellular apoptosis.

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Article information

DOI: https://doi.org/10.1039/D0AN02321C
Article type: Communication
Submitted: 03 دسمبر 2020
Accepted: 11 جنؤری 2021
First published: 11 جنؤری 2021

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Analyst, 2021,146, 1538-1542

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Acridinium benzoates for ratiometric fluorescence imaging of cellular viscosity

M. Wen, C. Li, M. Zhang, Y. Sun, F. Liu, X. Cui and Y. Shan, Analyst, 2021, 146, 1538 DOI: 10.1039/D0AN02321C

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Acridinium benzoates for ratiometric fluorescence imaging of cellular viscosity†

Abstract

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Acridinium benzoates for ratiometric fluorescence imaging of cellular viscosity

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