Issue 35, 2020

Revisiting the role of acids and hydrogen bond acceptors in enamine formation

Abstract

A systematic investigation into the effects of acids and hydrogen bond acceptors on the reaction rates and equilibria of enamine formation is reported. Acids can accelerate the reaction but do not change the reaction equilibria. In comparison, hydrogen bond acceptors facilitate the enamine formation via their strong hydrogen bonding interaction with the water generated in the reaction.

Graphical abstract: Revisiting the role of acids and hydrogen bond acceptors in enamine formation

Supplementary files

Article information

Article type
Paper
Submitted
30 جوٗلایی 2020
Accepted
18 اگست 2020
First published
18 اگست 2020

Org. Biomol. Chem., 2020,18, 6849-6852

Author version available

Revisiting the role of acids and hydrogen bond acceptors in enamine formation

Z. Lu, G. B. Hammond and B. Xu, Org. Biomol. Chem., 2020, 18, 6849 DOI: 10.1039/D0OB01579B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements