Issue 12, 2020

A chiral covalent organic framework (COF) nanozyme with ultrahigh enzymatic activity

Abstract

Herein, we report the first chiral nanozyme with higher activity than the natural enzyme, which is designed based on mimicking a natural enzyme and the superior structure of covalent organic framework (COF) materials. The well-dispersed iron porphyrin and L-histidine (L-His) units endow the COF nanozyme with high activity. The incorporation of L-His units also imbues the COF nanozyme with selectivity for L-dopa in the oxidation of dopa enantiomers with a selectivity factor up to 1.86, while replacing L-His with D-His can reverse the preference to D-dopa with a selectivity factor of 1.51. The activity and selectivity of the COF nanozyme can be optimized by varying the L-His content which can change the activation energy of the catalytic reactions and the substrate binding.

Graphical abstract: A chiral covalent organic framework (COF) nanozyme with ultrahigh enzymatic activity

Supplementary files

Article information

Article type
Communication
Submitted
23 ستمبر 2020
Accepted
20 اکتوٗبر 2020
First published
20 اکتوٗبر 2020

Mater. Horiz., 2020,7, 3291-3297

A chiral covalent organic framework (COF) nanozyme with ultrahigh enzymatic activity

Y. Zhou, Y. Wei, J. Ren and X. Qu, Mater. Horiz., 2020, 7, 3291 DOI: 10.1039/D0MH01535K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements