Issue 7, 2019

Highly regioselective α-alkylation of α,β,γ,δ-unsaturated aldehydes

Abstract

The first α-alkylation of α,β,γ,δ-unsaturated aldehydes is achieved under mild reaction conditions. Several α,β,γ,δ-unsaturated aldehydes and diarylcarbinols are successfully tested for the synthesis of MBH-type α-alkylated products with an excellent regioselectivity. Simple pyrrolidine is efficiently used as a catalyst to achieve a perfect E/Z selectivity of the α-alkylated products.

Graphical abstract: Highly regioselective α-alkylation of α,β,γ,δ-unsaturated aldehydes

Supplementary files

Article information

Article type
Communication
Submitted
22 اگست 2018
Accepted
05 ستمبر 2018
First published
05 ستمبر 2018

Org. Biomol. Chem., 2019,17, 1714-1717

Highly regioselective α-alkylation of α,β,γ,δ-unsaturated aldehydes

V. M. D. Padmaja, S. Jangra and C. Appayee, Org. Biomol. Chem., 2019, 17, 1714 DOI: 10.1039/C8OB02059K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements