Issue 24, 2019

Tuning crystallization and stability of the metastable polymorph of dl-methionine by a structurally similar additive

Abstract

Crystal engineering is aimed at controlling the crystal forms and desired properties from the view of molecular engineering, which is important for the production of high-value-added products. DL-Methionine (DL-met) usually crystallizes in a concomitant mixture with the known metastable α-form and stable β-form from a pure aqueous solution. In this contribution, we first applied molecular dynamics (MD) simulations to study the effects of the tailor-made additive and found that DL-leucine (DL-leu) might enable us to stabilize the metastable form. To validate our idea, we performed experiments including cooling crystallization with isothermal and non-isothermal methods, nucleation induction time measurements, solvent-mediated phase transformation and crystal growth rate measurements. It was found that on increasing the concentration of DL-leu, the nucleation of the β-form and the transformation of the α-form were hindered. When the concentration of DL-leu reached above 0.02 mol L−1, hexagonal crystals other than foliaceous crystals could be obtained. Hence, the metastable α-form of DL-met with fine crystal habits and high temporal stability was prepared.

Graphical abstract: Tuning crystallization and stability of the metastable polymorph of dl-methionine by a structurally similar additive

Supplementary files

Article information

Article type
Paper
Submitted
03 جنؤری 2019
Accepted
09 میٔ 2019
First published
09 میٔ 2019

CrystEngComm, 2019,21, 3731-3739

Tuning crystallization and stability of the metastable polymorph of DL-methionine by a structurally similar additive

Z. Li, P. Shi, Y. Yang, P. Sun, Y. Wang, S. Xu and J. Gong, CrystEngComm, 2019, 21, 3731 DOI: 10.1039/C9CE00009G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements