Issue 77, 2019

A supramolecular sensor array for selective immunoglobulin deficiency analysis

Abstract

A host–guest based fluorescence sensor array can sense small differences in protein structure. The combination of three cavitand hosts and two fluorophores to form a 4-component array is sufficient to fully discriminate five structurally similar Ig protein isotypes. The array can be applied to recognize Ig deficiencies in serum, when combined with a Protein L-based extraction process, allowing analysis of immunodeficiency in a simpler, lower cost manner than tests that require multiple specific antibodies.

Graphical abstract: A supramolecular sensor array for selective immunoglobulin deficiency analysis

Supplementary files

Article information

Article type
Communication
Submitted
05 اگست 2019
Accepted
02 ستمبر 2019
First published
03 ستمبر 2019

Chem. Commun., 2019,55, 11563-11566

Author version available

A supramolecular sensor array for selective immunoglobulin deficiency analysis

Y. Liu, A. D. Gill, Y. Duan, L. Perez, R. J. Hooley and W. Zhong, Chem. Commun., 2019, 55, 11563 DOI: 10.1039/C9CC06064B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements