Amidines bearing simple alkenes undergo aminal radical cyclisation upon treatment with SmI2. The mild, reductive electron transfer process delivers medicinally-relevant, polycyclic quinazolinone derivatives in good to excellent yield and typically with complete diastereocontrol.
H. Huang, R. W. Adams and D. J. Procter, Chem. Commun., 2018, 54, 10160 DOI: 10.1039/C8CC05178J
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