Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(II) complex

O. Hrabina; J. Kasparkova; T. Suchankova; V. Novohradsky; Z. Guo; Viktor Brabec

doi:10.1039/C7MT00052A

Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(ii) complex†

O. Hrabina,^ab J. Kasparkova,^b T. Suchankova,^a V. Novohradsky,^a Z. Guo

^c and Viktor Brabec

*^a

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* Corresponding authors

^a Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Kralovopolska 135, CZ-61265 Brno, Czech Republic
E-mail: brabec@ibp.cz

^b Department of Biophysics, Faculty of Science, Palacky University, 17. listopadu 12, CZ-77146 Olomouc, Czech Republic

^c State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China

Abstract

The DNA interstrand cross-links of the antitumor drug {[cis-Pt(NH₃)₂Cl]₂(4,4′-methylenedianiline)}²⁺ (1) play a prevalent role in its antitumor effects. Complex 1 forms DNA long-range interstrand cross-links uniquely in the 3′–3′ direction. Conformational distortions induced by these interstrand cross-links in DNA represent a potential structural motif for recognition by high-mobility-group proteins.

This article is part of the themed collection: Metallomics Recent HOT articles

Metallomics

Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(ii) complex†

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