Issue 2, 2017

A biotinylated piperazine-rhodol derivative: a ‘turn-on’ probe for nitroreductase triggered hypoxia imaging

Abstract

We developed a nitroreductase responsive theranostic probe 1; it comprises biotinylated rhodol in conjunction with p-nitrobenzyl functionality. The probe 1 showed a remarkable fluorescence ‘turn-on’ signal in the presence of nitroreductase under physiological conditions. The probe is considerably stable within a wide biological pH range (6–8) and also is very sensitive toward a reducing micro-environment e.g. liver microsome. Further, it enables providing cellular and in vivo nematode images in a reducing microenvironment.

Graphical abstract: A biotinylated piperazine-rhodol derivative: a ‘turn-on’ probe for nitroreductase triggered hypoxia imaging

Supplementary files

Article information

Article type
Paper
Submitted
20 ستمبر 2016
Accepted
30 نومبر 2016
First published
01 دسمبر 2016

Analyst, 2017,142, 345-350

A biotinylated piperazine-rhodol derivative: a ‘turn-on’ probe for nitroreductase triggered hypoxia imaging

Y. Zhou, K. N. Bobba, X. W. Lv, D. Yang, N. Velusamy, J. F. Zhang and S. Bhuniya, Analyst, 2017, 142, 345 DOI: 10.1039/C6AN02107G

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