Issue 20, 2014

Aggregation-induced emission dye based luminescent silica nanoparticles: facile preparation, biocompatibility evaluation and cell imaging applications

Abstract

In this work, we reported for the first time that luminescent silica nanoparticles could be easily fabricated by the encapsulation of an aggregation-induced emission dye (named An18) via a modified Stöber method. In this method, octadecyltrimethoxysilane (C18-Si) and An18 were first self assembled and served as the core of the silica nanoparticles. Then another silicate precursor, tetraethoxysilane, was further coated on the luminescent core, thus forming luminescent silica nanoparticles. The properties of the thus obtained luminescent silica nanoparticles (named An18-SiO2 NPs) were investigated by fluorescence spectroscopy, transmission electron microscopy and Fourier transform infrared spectroscopy. The biocompatibility and cell uptake behavior of the An18-SiO2 NPs were further investigated to evaluate their potential for biomedical applications. Our results demonstrated that the An18-SiO2 NPs have a uniform spherical morphology (with diameter of 70–80 nm), high water dispersibility, remarkable fluorescent properties and excellent biocompatibility, making them a promising candidate material for various biomedical applications.

Graphical abstract: Aggregation-induced emission dye based luminescent silica nanoparticles: facile preparation, biocompatibility evaluation and cell imaging applications

Supplementary files

Article information

Article type
Paper
Submitted
24 اکتوٗبر 2013
Accepted
11 دسمبر 2013
First published
11 دسمبر 2013

RSC Adv., 2014,4, 10060-10066

Aggregation-induced emission dye based luminescent silica nanoparticles: facile preparation, biocompatibility evaluation and cell imaging applications

X. Zhang, X. Zhang, B. Yang, L. Liu, J. Hui, M. Liu, Y. Chen and Y. Wei, RSC Adv., 2014, 4, 10060 DOI: 10.1039/C3RA46076B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements